Resistance-repellent retroviral protease inhibitors

Details Resistance-repellent retroviral protease inhibitors Resistance-repellent retroviral protease inhibitors

2007-10-23

2007-10-23

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S375000, C548S159000, C548S222000

Reexamination Certificate

active

10500888

ABSTRACT:
Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided.

REFERENCES:
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patent: 2005/0261364 (2005-11-01), Wang et al.
patent: 2005/0267074 (2005-12-01), Eissenstat et al.
patent: WO99/67254 (1999-12-01), None
patent: WO 200076961 (2000-12-01), None
Arun K. Ghosh et al., “Potent HIV Protease Inhibitors Incorporating High-Affinity P2-Ligands and (R)-(Hydroxyethylamino) sulfonamide Isostere”, Bioorganic & Medicinal Chemistry Letters, 1998, p. 687-690, vol. 8.
Arun K. Ghosh et al., “Structure Based Design: Novel Spirocyclic Ethers as Nonpeptidal P2-Ligands for HIV Protease Inhibitors”, Bioorganic & Medicinal Chemistry Letters, 1998, pp. 979-982, vol. 8.
Arun K. Ghosh et al., “Structure-based design of non-peptide HIV protease inhibitors”, IL FARMACO, Jan. 2001, pp. 29-32, vol. 56, No. ½.
Kazuhisa Yoshimura et al., “A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003(TMC-126), and Selection of a Novel (A282S) Mutation in the Protease Active Site”, Journal of Virology, Feb. 2002, pp. 1349-1358, vol. 76, No. 3.

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