Dipeptide and related compounds which inhibit leukocyte...

Details Dipeptide and related compounds which inhibit leukocyte... Dipeptide and related compounds which inhibit leukocyte...

2007-10-30

2007-10-30

Lukton, David (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S331000, C514S018700

Reexamination Certificate

active

10119238

ABSTRACT:
Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

REFERENCES:
patent: 4018913 (1977-04-01), Okamoto et al.
patent: 4018915 (1977-04-01), Okamoto et al.
patent: 4036955 (1977-07-01), Okamoto et al.
patent: 4041156 (1977-08-01), Okamoto et al.
patent: 4046876 (1977-09-01), Okamoto et al.
patent: 4055636 (1977-10-01), Okamoto et al.
patent: 4055651 (1977-10-01), Okamoto et al.
patent: 4069318 (1978-01-01), Okamoto et al.
patent: 4070457 (1978-01-01), Okamoto et al.
patent: 4071621 (1978-01-01), Okamoto et al.
patent: 4073914 (1978-02-01), Kikumoto et al.
patent: 4074057 (1978-02-01), Kawamatsu et al.
patent: 4096255 (1978-06-01), Kikumoto et al.
patent: 4097591 (1978-06-01), Okamoto et al.
patent: 4104392 (1978-08-01), Okamoto et al.
patent: 4804676 (1989-02-01), Inaoka et al.
patent: 4910190 (1990-03-01), Bergeson et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 4981873 (1991-01-01), Witte et al.
patent: 5036053 (1991-07-01), Himmelsbach et al.
patent: 5338755 (1994-08-01), Wagnon et al.
patent: 5362901 (1994-11-01), Wagner et al.
patent: 5362902 (1994-11-01), Barnish et al.
patent: 5397801 (1995-03-01), Wagnon et al.
patent: 5481005 (1996-01-01), Wagnon et al.
patent: 5578633 (1996-11-01), Wagnon et al.
patent: 5650428 (1997-07-01), Ohmori et al.
patent: 5686628 (1997-11-01), Veale et al.
patent: 6221888 (2001-04-01), Durette et al.
patent: 6147073 (1975-04-01), None
patent: 23 57 334 (1974-06-01), None
patent: 26 55 636 (1977-06-01), None
patent: 0 526 348 (1993-02-01), None
patent: 04 154732 (1992-05-01), None
patent: 06 16625 (1994-01-01), None
patent: 08 073422 (1996-03-01), None
patent: WO92/16549 (1992-10-01), None
patent: WO94/07815 (1994-04-01), None
patent: WO94/12181 (1994-06-01), None
patent: WO95/15973 (1995-06-01), None
patent: WO96/20725 (1996-07-01), None
patent: WO96/20949 (1996-07-01), None
patent: WO96/22966 (1996-08-01), None
patent: 97/03094 (1997-01-01), None
patent: WO97/03094 (1997-01-01), None
patent: WO98/04247 (1998-02-01), None
patent: WO98/53814 (1998-12-01), None
patent: WO98/53817 (1998-12-01), None
patent: WO98/53818 (1998-12-01), None
patent: WO98/54207 (1998-12-01), None
patent: 99/06436 (1999-02-01), None
patent: WO99/10312 (1999-03-01), None
patent: WO99/10313 (1999-03-01), None
Kibirev, V. K. (Chem. Pept. Proteins, Proc. USSR-FRG Symp., 3rd (1982), Meeting Date 1980, 353-7. Editor(s): Voelter, Wolfgang; Wuensch, Erich; Ovchinnikov, Yu. Publisher: de Gruyter, Berlin, Fed. Rep. Ger).
Supattapone, Surachai (Journal of Neurochemistry 42(4), 1017-23, 1984).
Simanis, Viesturs (International Journal of Peptide & Protein Research (1982), 19(1), 67-70).
Miyoshi, Muneji, Chemical & Pharmaceutical Bulletin 17(8), 1617-22, 1969.
V. Simanis et al.,Int. J. Pept. Protein Res. (1982), 19(1), 67-70.
D. Leibfritz et al.,Tetrahedron(1982), 38(14), 2165-81.
A. M. El-Naggar et al.,Acta. Pharm. Jugosl. (1985), 35(1), 15-22.
Chemical Abstract No. 126040, vol. 74, No. 23 (Jun. 7, 1971).
Chemical Abstract No. 176262, vol. 99, No. 21 (Nov. 21, 1983).
Chemical Abstract No. 210288, vol. 106, No. 25 (Jun. 22, 1987).
Chemical Abstract No. 167952, vol. 108, No. 19 (May 9, 1988).
Chemical Abstract No. 34164, vol. 125, No. 3 (Jul. 15, 1996).
Leibfritz, D., et al. “Synthese Von 2-Methylalanin-Peptiden, Die pH-Abhangigkeit Ihrer 13C-NMR-Spektren Und Eine Neue Methode Zur Auswetung Uber CS-Diagramme.”Tetrehedron. 18(14):2165-2181 (1982).
Voigt, B., et al. Synthese von Nα-(Arylsolfonyl-L-prolyl)-und Nα-Benzyloxycarbonyl-L-prolyl)-D,L-4-amidinophenyl-alaninamiden als.
Thrombininhibitoren.Pharmazie. 41: 233-235 (1986).
Hauptmann, J., et al. “Degradation of a Benzamidine-Type Synthetic Inhibitor of Coagulation Enzymes in Plasma of Various Species.”Thrombosis Research. 61: 279-284 (1991).
Gamo, K. “Optical resolution of racemic amine derivatives.”Chem. Abs. 117:211689 (1992).
Engleman, V.W., et al. “Cell Adhesion Integrins as Pharmaceutical Targets.”Ann. Reports in Med. Chem. 31: 191-200 (1996).

Affiliated with

Also associated with

Rating

Dipeptide and related compounds which inhibit leukocyte... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dipeptide and related compounds which inhibit leukocyte..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dipeptide and related compounds which inhibit leukocyte... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3901384