Small molecule inhibitors of necrosis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

10880377

ABSTRACT:
The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.

REFERENCES:
patent: 4837165 (1989-06-01), Hawke
patent: 5693643 (1997-12-01), Gilbert et al.
patent: 5962535 (1999-10-01), Miyamoto et al.
patent: 02019363 (1990-01-01), None
Borner and Monney, “Apoptosis without Caspases: An Inefficient Molecular Guillotine?”Cell Death Differ.6:497-507 (1999).
Büyükbingöl et al., “Studies on the Synthesis and Structure-Activity Relationships of 5-(3′-Indolal)-2-Thionydantoin Derivatives as Aldose Reductase Enzyme Inhibitors,”Farmaco, 49:443-447 (1994).
Chi et al., “Oncogenic Ras Triggers Cell Suicide Through the Activation of a Caspase-Independent Cell Death Program in Human Cancer Cells,”Oncogene18:2281-2290 (1999).
Edman, “Method for Determination of the Amino Acid Sequence in Peptides,”Acta Chem. Scand.4:283-293 (1950).
Fiers et al., “More Than One Way to Die: Apoptosis, Necrosis and Relative Oxygen Damage,”Oncogene18:7719-7730 (1999).
Fujiwara et al., “13C Nuclear Magnetic Resonance Studies on the Conformation of Substituted Hydantoins,”J. Chemical Soc. Perkin.2:1573-1577 (1980).
Herceg and Wang, “Failure of Poly(ADP-Ribose) Polymerase Cleavage by Caspases Leads to Induction of Necrosis and Enhanced Apoptosis,”Mol. Cell. Biol.19:5124-5133 (1999).
Hirsch et al., “The Apoptosis-Necrosis Paradox. Apoptogenic Proteases Activated After Mitochondrial Permeability Transition Determine the Mode of Cell Death,”Oncogene15:1573-1581 (1997).
Holler et al., “Fas Triggers an Alternative, Caspase-8-Independent Cell Death Pathway Using the Kinase RIP as Effector Molecule,”Nature Immunol.1:489-495 (2000).
Kawahara et al., “Caspase-Independent Cell Killing by Fas-Associated Protein with Death Domain,”J. Cell. Biol.143:1353-1360 (1998).
Khwaja and Tatton, “Resistance to the Cytotoxic Effects of Tumor Necrosis Factor Alpha can be Overcome by Inhibition of a FADD/Caspase-Dependent Signaling Pathway,”J. Biol. Chem.274:36817-23 (1999).
Kitanaka and Kuchino, “Caspase-Independent Programmed Cell Death with Necrotic Morphology,”Cell Death Differ.6:508-515 (1999).
Leist et al., “Inhibition of Mitochondrial ATP Generation by Nitric Oxide Switches Apoptosis to Necrosis,”Exp. Cell Res.249:396-403 (1999).
Li and Beg, “Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells,”J. Virol.74:7470-7477 (2000).
Lüschen et al., “Sensitization to Death Receptor Cytotoxicity by Inhibition of Fas-Associated Death Domain Protein (FADD)/Caspase Signaling. Requirement of Cell Cycle Progression,”J. Biol. Chem.275:24670-24678 (2000).
Matsumura et al., “Necrotic Death Pathway in Fas Receptor Signaling,”J. Cell. Biol.151:1247-1255 (2000).
McCarthy et al., “Inhibition of Ced-3/ICE-Related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak,”J. Cell. Biol.136:215-227 (1997).
Molina et al., “A Simple and General Entry to Aplysinopsine-Type Alkaloids by Tandem Aza-Wittig/Heterocumulene-Mediated Annelation,”Tet. Lett.33:4491-4494 (1992).
Sané and Bertrand, “Caspase Inhibition in Camptothecin-Treated U-937 Cells is Coupled with a Shift from Apoptosis to Transient G1 Arrest Followed by Necrotic Cell Death,”Cancer Res.59:3565-3569 (1999).
Takahashi et al., “Antimutagenic Properties of 3,5-Disubstituted 2-Thiohydantoins,”J. Agric. Food Chem.46:5037-5042 (1998).
Vercammen et al., “Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor,”J. Exp. Med.187:1477-1485 (1998).
Vercammen et al., “Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways,”J. Exp. Med.188:919-930 (1998).
Waterfield and Haber, “Amino Acid Sequence Analysis with Methyl Isothiocyanate Resolution of the Methylthiohydantoins by Gas—Liquid Partition Chromatography,”Biochemistry9:832-839 (1970).
Woo, “Gas-Chromatographic Determination of Methylthiogydantoin Amino Acid as N(O)-Butlydimethylsilyl Derivatives in Amino Acid Sequencing with Methylisothiocyanate,”J. Korean Agric. Chem. Soc.35:132-138 (1992).
Inglis et al., “The Identification of Tryptophan Residues in Proteins as Oxidized Derivatives During Amino Acid Sequence Determinations,”FEBS Lett.104:115-118 (1979) (Abstract).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Small molecule inhibitors of necrosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Small molecule inhibitors of necrosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Small molecule inhibitors of necrosis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3897625

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.