Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-12-25
2007-12-25
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S336000, C514S340000, C514S617000, C546S268100, C546S309000, C564S184000
Reexamination Certificate
active
10576762
ABSTRACT:
The present invention relates to compounds of formula I:or a pharmaceutically acceptable acid addition salt thereof, where;X is —C(R4)═ or —N═;Ar is phenyl, substituted phenyl, heterocycle, or substituted heterocycle;R1and R2are independently hydrogen or C1-C3alkyl;R3is hydrogen, fluoro, or methyl;when X is —C(R4)═,R4is hydrogen, fluoro, or methyl, provided that no more than one of R3and R4may be other than hydrogen; andR5is hydrogen, methyl, or ethyl. The compounds of the present invention are useful for activating5-HT1Freceptors, inhibiting dural protein extravasation, and for the treatment or prevention of migraine in a mammal.
REFERENCES:
patent: 5521196 (1996-05-01), Audia et al.
patent: 5521197 (1996-05-01), Audia
patent: 5708187 (1998-01-01), Flaugh et al.
patent: 5721252 (1998-02-01), Audia et al.
patent: 5814653 (1998-09-01), Flaugh et al.
patent: 6384034 (2002-05-01), Simitchieva et al.
patent: WO 96/29075 (1996-09-01), None
patent: WO 97/13512 (1997-04-01), None
patent: WO 98/08502 (1998-03-01), None
patent: WO 98/15545 (1998-04-01), None
patent: WO 98/20875 (1998-05-01), None
patent: WO 98/46570 (1998-10-01), None
patent: WO 98/55115 (1998-10-01), None
patent: WO 99/25348 (1999-05-01), None
patent: WO 00/00487 (2000-01-01), None
patent: WO 00/00490 (2000-01-01), None
patent: WO 00/34266 (2000-06-01), None
patent: WO 00/47559 (2000-08-01), None
patent: WO 00/50426 (2000-08-01), None
patent: WO 03/008455 (2003-01-01), None
patent: WO 03/008494 (2003-10-01), None
Adham, N, et a.l., “Cloning of another human serotonin receptor (5-HT1F): A fifth 5-HT1receptor subtype coupled to the inhibition of adenylate cyclase”,Proc, Natl, Acad. Sci USA, vol. 90-408-412, 1993.
Kohlman Daniel Timothy
Victor Frantz
Xu Yao-Chang
Ying Bai-Ping
Zhang Deyi
Davis Zinna N.
Eli Lilly and Company
Tucker R. Craig
LandOfFree
Substituted (4-aminocyclohexen-1-yl)phenyl and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted (4-aminocyclohexen-1-yl)phenyl and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted (4-aminocyclohexen-1-yl)phenyl and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3895540