Protein tyrosine kinase agonist antibodies

Details Protein tyrosine kinase agonist antibodies Protein tyrosine kinase agonist antibodies

1994-04-04

1997-06-03

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

5303877, 53038826, 4241461, 4241381, 4241551, 435334, 435338, 435330, C07K 1600, A61K 39395, C12N 512

Patent

active

056351771

ABSTRACT:
Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.

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