Aerosol drug formulations containing polyglycolyzed glycerides

Details Aerosol drug formulations containing polyglycolyzed glycerides Aerosol drug formulations containing polyglycolyzed glycerides

1994-08-26

1997-06-03

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, A61K 912

Patent

active

056351593

ABSTRACT:
Pharmaceutical compositions for aerosol delivery comprising (a) a medicament, (b) a non-chlorofluorocarbon propellant, and (c) a polyglycolized glyceride having a hydrophilic lipophilic balance of between and including 6 and 14, wherein the medicament is present in a concentration of between about 0.05% and about 5% by weight and the polyglycolized glyceride is present in a concentration of between about 0.001% and about 10% by weight, the nonchlorofluorocarbon propellant is selected from the group consisting of HCFC 123, HCFC 124, HCFC 141b, HCFC 225, HCFC 125, FC-C 51-12, DYMEL A, DYMEL 152a, HFC 134a and HFC 227ea in which unwanted aggregation of the medicament is prevented without the use of surfactants, protective colloids or cosolvents.

REFERENCES:
patent: 4851211 (1989-07-01), Adjei et al.
patent: 4897256 (1990-01-01), Adjei et al.

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