Microarray reaction cartridge

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

10092285

ABSTRACT:
An apparatus and method are provided for shipping, storing, and high-throughput processing of microarrays. An exemplary microarray cartridge according to the present invention includes a body having a cavity defined by an outer surface and two dimple features in fluid communication with the cavity. The cavity includes at least one ledge for supporting a microarray of biological probes, and a reaction chamber defined at least in part by the ledge. A plate covers the cavity and sealingly attaches to the outer surface of the body. Ports in the plate or the dimple features allow introduction of sample, reaction and wash solutions into the reaction chamber such that the solutions contacts the probes on the microarray. The disposable microarray cartridges of the present invention are used to package and store microarrays prior to use and to process microarrays in a high-throughput manner. The footprint of the cartridge is designed to be compatible with standard robotic formats or standard re-formatting approaches.

REFERENCES:
patent: 3582285 (1971-06-01), Hamilton
patent: 3726597 (1973-04-01), Dvorak et al.
patent: 4435508 (1984-03-01), Gabridge
patent: 5417576 (1995-05-01), Hill
patent: 5474796 (1995-12-01), Brennan
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5539083 (1996-07-01), Cook et al.
patent: 5543114 (1996-08-01), Dudek
patent: 5545522 (1996-08-01), Van Gelder et al.
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5578832 (1996-11-01), Trulson et al.
patent: 5716785 (1998-02-01), Van Gelder et al.
patent: 5770441 (1998-06-01), Lipton
patent: 5891636 (1999-04-01), Van Gelder et al.
patent: 5922591 (1999-07-01), Anderson et al.
patent: 5955028 (1999-09-01), Chow
patent: 6028189 (2000-02-01), Blanchard
patent: 6043080 (2000-03-01), Lipshutz et al.
patent: 6050719 (2000-04-01), Winkler et al.
patent: 6140044 (2000-10-01), Besemer et al.
patent: 6159727 (2000-12-01), Bochikariov
patent: 6203987 (2001-03-01), Friend et al.
patent: 6225645 (2001-05-01), Zhang
patent: 6238910 (2001-05-01), Custance et al.
patent: 6258593 (2001-07-01), Schembri et al.
patent: 6271002 (2001-08-01), Linsley et al.
patent: 6534008 (2003-03-01), Angros
patent: 6602702 (2003-08-01), McDevitt et al.
patent: 6803019 (2004-10-01), Bjornson et al.
patent: WO 98/41531 (1998-09-01), None
patent: WO 99/66024 (1999-12-01), None
patent: WO 00/24936 (2000-05-01), None
patent: WO 01/05935 (2001-01-01), None
Baltimore, 2001, “Our genome unveiled”, Nature 409:814-816.
Blanchard et al., 1996, “High-Density oligonucleotide arrays”, Biosensors and Bioelectronics 11:687-690.
Bonaldo et al., 1996, “Normalization and Subtraction: Two Approaches to Facilitate Gene Discovery” Genome Research 6:791-806.
Chirgwin et al., 1979, “Isolation of biologically active ribonucleic acid from sources enriched in ribionuclease”, Biochemistry 18:5294-5299.
DeRisi et al., 1996, “Use of a cDNA microarray to analyse gene expression patterns in human cancer”, Nature Genetics 14:457-460.
de Wildt et al., 2000, “Antibody arrays for high throughput screening of antibody-antigen interactions”, Nature Biotechnology 18:989-994.
Egholm et al., 1993, “PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules”, Nature 365:566-568.
Fodor et al., 1991, “Light-directed, spatially addressable parallel chemical synthesis”, Science 251:767-773.
Froehler et al., 1986, “Synthesis of DNA via deoxynucleoside H-phosphonate intermediates”, Nucleic Acids Research 14:5399-5407.
Goffeau et al. 1996, “Life with 6000 genes”, Science 274:546-567.
Hughes et al., 2001, “Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer”, Nature Biotechnology 19:342-347.
Lockhart et al., 1996, “Expression monitoring by hybridization to high-density oligonucleotide arrays”, Nature Biotechnology 14:1675-1680.
MacBeath and Schreiber, 2000, “Printing proteins as microarrays for high-throughput function determination” Science 289:1760-1763.
Maskos and Southern, 1992, “Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesised in situ”, Nucleic Acids Research 20:1679-1684.
McBride et al., 1983, “An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides”, Tetrahedron Letters 24:245-248.
Nguyen et al., 1995, “Differential gene expression in the Murine Thymus Assayed by quantitative hybridization of arrayed cDNA clones”, Genomics 29:207-216.
Pease et al., 1994, “Light-generated oligonucleotide arrays for rapid DNA sequence analysis”, Proc. Natl. Acad. Sci. USA 91:5022-5026.
Rogers et al., 2000, “The Global Spread of Malaria in a Future, Warmer World”, Science, 289:1763.
Ross et al., 2000, “Systsematic variation oin gene expression patterns in human cancer cell lines”, Nature Genetics 24:227-235.
Schena et al., 1995, “Quantitative monitoring of gene expression patterns with a complementary DNA microarray”, Science 270:467-470.
Schena et al., 1996, “Parallel human genome analysis; microarray-based expression of 1000 genes”, Proc. Natl. Acad. Sci. USA 93:10614-10619.
Shalon et al., 1996, “A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization”, Genome Research 6:639-645.
Zhu et al., 2001, “Global analysis of protein activities using proteome chips”, Science 293:2101-2105.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Microarray reaction cartridge does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microarray reaction cartridge, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microarray reaction cartridge will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3891376

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.