Aspartate carbamyltransferase as herbicidal target

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

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C435S193000, C536S023200

Reexamination Certificate

active

10204836

ABSTRACT:
The present invention relates to the use of DNA sequences of plant origin encoding a polypeptide with aspartate carbamyltransferase (E.C. 2.1.3.2) activity for generating an assay system for finding aspartate carbamyltransferase inhibitors. For the first time, it was shown, with the aid of antisense technology, that aspartate carbamyltransferase constitutes a herbicidal target.

REFERENCES:
Guo et al. (Jun. 22, 2004) PNAS, vol. 101, No. 25, pp. 9205-9210.
Hoefgen et al., Plant Physiol(1995) 107:469-477.
Overduin et al., Plant Physiol. vol. 105,1994, 43-48.
Williamson et al., Plant Physiol., (1994)105:377-384.
Acaster et al., Carbamoyltransferase reactions . . . analogue inhibitors. J. Exp Botany. 40: 1121-1126, 1989.
Lovatt et al. Aspartate carbamyl . . . early-prolific-straightneck. Plant Phys. 75: 511-515, 1984.
Williamson et al. Molecular cloning . . . transcarbamoylase in pea (Pisum sativumL.). Plant Phys. 105: 377-388, 1993.

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