Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-06-26
2007-06-26
McGarry, Sean (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
10730614
ABSTRACT:
A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.
REFERENCES:
patent: 4745119 (1988-05-01), Krenitsky
patent: 6235513 (2001-05-01), Rothe et al.
patent: 6258579 (2001-07-01), Mercurio et al.
patent: 6395545 (2002-05-01), Monia et al.
patent: 6649637 (2003-11-01), Curiel
patent: 2002/0132788 (2002-09-01), Lewis et al.
patent: 2003/0124726 (2003-07-01), De Fougerolles et al.
patent: 2003/0143540 (2003-07-01), Matsuda et al.
patent: 2003/0170719 (2003-09-01), Matsuda et al.
patent: 2004/0014111 (2004-01-01), Li et al.
patent: 2006/0073120 (2006-04-01), Li et al.
A. O'Mahony, et al. “Activation of the Heterodimeric IkB Kinase alpha (IKKalpha)-IKKbeta Complex is Directional: IKKalpha Regulates IKKbeta under both Basal and Stimulated Conditions”, Mol. and Cell.Bio., vol. 20, No. 4, pp. 1170-1178, 2000.
I. S. Bhullar, et al. “Fluid Shear Stress Activation of IkB Kinase is Integrin-dependent”, J. Bio. Chem. vol. 273, No. 46, pp. 30544-30549, 1998.
M. C.-T. Hu, et al. “IkB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes”, Gene, vol. 222, pp. 31-40, 1998.
J. D. Thompson “Applications of antisense and siRNAs during preclinical drug development”, Drug Discovery Today, vol. 7, No. 17, pp. 912-917, 2002.
S. Agrawal, et al. “Antisense therapeutics: is it as simple as complementary base recognition?”, Mol. Med. Today, vol. 6, pp. 72-81, 2000.
Pahl, H.L., “Activators and Target Genes of Rel/NF-kB Transription Factors”, Oncogene, 1999, vol. 18, pp. 6853-6866.
Mercurio, F., et al. “NF-kB as a Primary Regulator of the Stress Response”, Oncogene, 1999, vol. 18, pp. 6163-6171.
Barkett, M., et al. “Control of Apoptosis by Rel/NF-kB Transcription Factors”, Oncogene, 1999, vol. 18, pp. 6910-6924.
Karin, M., “How NF-kB is activated: The Role of the lkB Kinase (IKK) Complex”, Oncogene, 1999, vol. 18, pp. 6867-6874.
Jiang, M., et al. “Selective Silencing of Viral Gene Expression in HPV-Positive Human Cervical Carcinoma Cells Treated with siRNA, a Primer of RNA Interference”, Oncogene, 2002, vol. 21, pp. 6041-6048.
Jobin, C., et al. “The lkB/NF-kB System: A Key Determinant of Mucosal Inflammation and Protection”, American Journal of Physiology, Cellular Physiology, vol. 278, pp. 451-462, 2000.
Siebenlist, U., et al.; “Structure, Regulation and Function of NF-kappaB”; Annual Review of Cell Biology, Nov. 1994, vol. 10, pp. 405-455.
Baldwin, A., Jr., et al. “The NF-kB and lkB Proteins: New Discoveries and Insights”, Annual Review of Immunology, 1996, vol. 14, pp. 649-681.
Ghosh, S., et al., “NF-kB and Rel Proteins: Evolutionarily Conserved Mediators of Immune Responses”, Annual Review of Immunology, 1998, vol. 16, pp. 225-260.
Li, Z. W., et al. “The IKKb Subunit of lkB Kinase (IKK) is Essential for Nuclear Factor kB Activation and Prevention of Apoptosis”, Journal of Experimental Medicine, 1999, vol. 189, No. 11, pp. 1839-1845.
Li, X., et al. “IKKa, IKKb, and NEMO/IKKy Are Each Required for the NF-kB-Mediated Inflammatory Response Program”, The Journal of Biological Chemistry, 2002, vol. 277, No. 47, pp. 45129-45140.
Hu, Y., et al, “Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKa Subunit of lkB Kinase”, Science, 1999, vol. 284, pp. 316-320.
Anest, V., et al. “A Nucleosomal Function for lkB Kinase-a In NF-kB-dependent Gene Expression”, Nature, 2003, vol. 423, pp. 659-663.
Fire, A., et al., “Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis Elegans”, Nature, 1998, vol. 391, pp. 806-811.
Elbashir, S. M., et al. “Duplexes of 21-nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells”, Nature, 2001, vol. 411, pp. 494-498.
Hannon, G.J., et al. “RNA Interference”, Nature, 2002, vol. 418, pp. 244-250.
Sharp, P.A., et al. “sIRNA-directed inhibition of HIV-1 Infection”, Nature Medicine, 2002, vol. 8, pp. 681-687.
Irie, N., et al. “Subtype-and Species-Specific Knockdown of PKC using Short Interfering RNA”, Biochemical and Biophysical Research Communications, 2002, vol. 298, pp. 738-743.
Sharp, P.A., “RNA Interference - 2001”, Genes and Development, 2001, vol. 15, pp. 485-490.
McManus, M.T., et al. “Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes”, Journal of Immunology, 2002, vol. 169, pp. 5754-5760.
Charles A. Parkos, et al. “Primary structure and unique expression of the 22-kilodaiton light chain of human neutrophll cytochrome beta”; Proc. Natl. Acad. Sci. USA; vol. 85, pp. 3319-3323; 1988.
Fang Qian, et al. “The Structure of the Mouse Cathepsin B Gene and Its Putative Promoter”; DNA and Cell Biology, vol. 10, No. 3, pp. 159-168, 1991.
Mark E. Rosenberg, et al. “Clusterin: Physiologic and Pathophysiologic Considerations”; Int. J. Biochem. Cell. Biol., vol. 27, No. 7, pp. 633-645, 1995.
Yinling Hu, et al. “IKKalpha controls formation of the epidermis independently of NF-kB”; NATURE , vol. 410, pp. 710-714, 2001.
Amer A. Beg, et al. “Embryonic Lethality and Liver Degeneration in Mice Lacking the RelA Component of NF-kB”; NATURE; vol. 376; pp. 167-170, 1995.
Robyn Starr, et al. “A Family of Cytokine-Inducible Inhibitors of Signalling”; NATURE, vol. 387, pp. 917-921, 1997.
Mary C. Dinauer, et al. “Human Neutrophil Cytochrome b Light Chain (p22-phox)” J. Clin. Invest. vol. 86, pp. 1729-1737, 1990.
John R. Silkensen, et al. “The Role of Clusterin in Tissue Injury”, Biochem. Cell. Biol. vol. 72, pp. 483-488, 1994.
Constantin Makris, et al. “Femal Mice Heterozygous for IKKy/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmentl”; Molecular Cell, vol. 5, pp. 969-979, 2000.
Marc Schmidt-Supprian, et al. “NEMO/IKKy-Deficient Mice Model Incontinentia Pigmentl” Molecular Cell, vol. 5, pp. 981-992, 2000.
Yixue Cao, et al. “IKKalpha Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development”, Cell, vol. 107, pp. 763-775, 2001.
Vigo Heissmeyer, et al. “Shared Pathways of lkB Kinase-Induced SCF -Mediated Ubiqultination and Degradation for the NF-kB Precursor p105 and lbBalpha”, Mol. Cell. Biol. vol. 21, No. 4, pp. 1024-1035, 2001.
Mark E. Rosenberg, et al. “Apollpoprotein J/Clusterin Prevents a Progressive Glomerulopathy of Aging”, Mol. Cell. Biol., vol. 22, No. 6, pp. 1893-1902, 2002.
Tommaso Zanocco-Marani, et al. “Biological Activities and Signaling Pathways of the Granulin/Epithelin Precursor”, Cancer Research, vol. 59, pp. 5331-5340, 1999.
Minoru Tanaka, et al. “Reconstitution of the Functional Mouse Oncostatin M (OSM) Receptor: Molecular Cloning of the Mouse OSM Receptor Beta Subunit”, Blood, vol. 93, No. 3, pp. 804-815, 1999.
John C. Groskopf, et al. “Proliferin Induces Endothelial Cell Chemotaxis through a G Protein-Coupled, Mitogen-Activated Protein Kinase-Dependent Pathway”, Endocrinology, vol. 138, No. 7, pp. 2835-2840, 1997.
Daniel J. Toft, et al. “Reactivation of Proliferin gene expression is associated with increased anglogenesis in a cell culture model of fibrosarcoma tumor progression”, PNAS, vol. 98, No. 23, pp. 13055-13059, 2001.
Steven S. Smith, et al. “Mechanism of Human Methyl-directed DNA methyltransferase and the fidelty of cytosine methylation”, Proc. Natl. Acad. Sci. USA, vol. 89, pp. 4744-4748, 1992.
Yujing Liu, et al. “Mouse model of G acti
Li Jun
Li Xiang
Yang Jianfei
Boehringer Ingelheim Pharmaceuticals Inc.
Devlin Mary-Ellen M.
Dow David
Gibbs Terra C.
McGarry Sean
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