Monoclonal antibodies against ricin toxin and methods of...

Details Monoclonal antibodies against ricin toxin and methods of... Monoclonal antibodies against ricin toxin and methods of...

2007-02-13

2007-02-13

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C530S387100, C435S325000

Reexamination Certificate

active

10896875

ABSTRACT:
Disclosed herein are monoclonal antibodies (Mabs) against ricin toxin and its subunits. The Mabs were initially selected based upon their ability to bind to ricin and its individual subunits in a solid-phase enzyme-linked immunoassay (ELISA). Several candidates were selected for further evaluation, including their ability to inhibit ricin intoxication in vitro and for their utility as immunodiagnostic reagents. As disclosed herein, the Mabs may be used in immunoassays. Also disclosed, are use of the Mabs to inhibit ricin-mediated eukaryotic cell cytotoxicity in vitro, thereby indicating that these Mabs may be used to prevent and treat ricin intoxication in vivo. Kits comprising the Mabs are also disclosed.

REFERENCES:
patent: 5626844 (1997-05-01), Lemley
patent: 5858682 (1999-01-01), Gruenwald
Casadevall, Emerging Infectious Diseases, vol. 8, No. 8, pp. 833-841, 2002.
Colombatti et al. (1987) “Identification and Characterization of a Monoclonal Antibody Recognizing a Galactose-Binding Domain of the Toxin Ricin” J. Immunol. 138(9):3339-3344.
Colombatti et al. (1986) “Monoclona Antibodies Against Ricin: Effects on Toxin Function” Hybridoma 5(1):9-19.
Lemley et al. (1994) “Identification and Characterization of a Monoclonal Antibody that Neutralizes Ricin Toxicity in Vitro and in Vivo” Hybridoma 13(5):417-421.
Poli et al. (1996) “Aerosolized Specific Antibody Protects Mice from Lung Injury Associated with Aerosolized Ricin Exposure” Toxicon 34(9):1037-1044.
Shyu et al. (2002) “Monoclonal Antibody-Based Enzyme Immunoassay for Detection of Ricin” Hybridoma and Hybridomics 21(1):69-73.

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