Process for the preparation of a piperazine derivative

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S106000

Reexamination Certificate

active

10297592

ABSTRACT:
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-4-[2-[(2S)-2-(methoxymethyl)morpholino]ethyl]-2-(3-hydroxy-4-methylbenzyl)piperazine dihydrochloride is obtained by debenzylating (2R)-4-benzyl-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(3-hydroxy-4-methylbenzyl)piperazine, then N-alkylating and converting to hydrochloride.

REFERENCES:
patent: 5670505 (1997-09-01), Matsuo et al.
patent: 5883098 (1999-03-01), Matsuo et al.
patent: 96/34864 (1996-11-01), None
patent: 97/08166 (1997-03-01), None
patent: 97/22597 (1997-06-01), None
patent: 98/57954 (1998-12-01), None
patent: WO 9857954 (1998-12-01), None
patent: 00/35915 (2000-06-01), None
patent: WO 200035915 (2000-06-01), None

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