Nucleic acid-based compounds and methods of use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S042000

Reexamination Certificate

active

11057779

ABSTRACT:
The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.

REFERENCES:
patent: 5212295 (1993-05-01), Cook
patent: 5218103 (1993-06-01), Caruthers et al.
patent: 5547941 (1996-08-01), Battistini et al.
patent: 5614504 (1997-03-01), Hadden et al.
patent: 5773431 (1998-06-01), Javitt
patent: 5843912 (1998-12-01), Hosmane et al.
patent: 6620796 (2003-09-01), Zhou et al.
patent: 4111730 (1991-04-01), None
patent: 2641537 (2001-05-01), None
patent: WO 90/07520 (1990-07-01), None
patent: WO 90/12578 (1990-11-01), None
patent: WO 92/18520 (1992-10-01), None
patent: WO 94/00472 (1994-01-01), None
patent: WO 94/00473 (1994-01-01), None
patent: WO 94/22864 (1994-10-01), None
patent: WO 95/32984 (1995-12-01), None
patent: WO 96/10030 (1996-04-01), None
patent: WO 96/39154 (1996-12-01), None
patent: WO 96/39413 (1996-12-01), None
patent: WO 96/39502 (1996-12-01), None
patent: WO 97/19092 (1997-05-01), None
patent: WO 98/30575 (1998-07-01), None
patent: WO 99/64378 (1999-12-01), None
patent: WO 01/34622 (2001-05-01), None
patent: WO 01/40515 (2001-06-01), None
patent: WO 2002/043771 (2002-06-01), None
patent: WO 02/081494 (2002-10-01), None
Matsukura et al. Proc. Natl. Acad. Sci. USA (1987), vol. 84, pp. 7706-7710.
Zhou, W. et al., “Combinatorial Synthesis using nucleic acid-based NAB™ scaffold: parallel solid-phase synthesis of nucleotide libraries,”Tetrahedron Letters,41:441-445 (2000).
Davis, Peter W. et al., Communications to the Editor: “Drug Leads from Combinatorial Phosphodiester Libraries,”Med. Chem.,38:4363-4366 (1995).
International Search Report (May 2001).
Moriguchi et al. Chemical Abstracts, vol. 131:228913 (1999).
Ma et al., Chemical Abstracts, vol. 11:133624 (1995).
Cummins et al., Chemical Abstracts, vol. 106;115671 (1987).
Cummins et al., Chemical Abstracts, vol. 103:215702 (1985).
Jin, Yi, et al., “Parallel Solid-Phase Synthesis of Nucleoside Phosphoramidate Libraries,”Bioorganic&Medical Chemistry Letters,11: 2057-2060 (2001).
Asseline, Ulysse, et al., “Synthesis and Binding Properties of Oligonucleotides Covalently Linked to an Acridine Derivative: New Study of the Influence of the Dye Attachment Site,”Bioconjugate Chem.,7: 369-379 (1996).
Kumar, Prabhat, and Misra, K., “A New Strategy for the Synthesis of Phosphorothioates of 2'-Deoxyriboligonucleotides,”Indian J. of Chemistry,36B: 1000-1004 (1997).
Ravikumar, Vasulinga T., et al., “4-Cyano-2-Butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis Via Phosphoramidite Approach,”Nucleosides&Nucleotides,16(7-9): 1709-1712 (1997).
Brill, Wolfgang K.-D., et al., “Synthesis of Oligodeoxynucleoside Phosphorodithioates via Thioamidites,”J. Am. Chem. Soc., 111: 2321-2322 (1989).
Agrawal, S., “Antisense Oligonucleotides as Antiviral Agents,”Trends in Biotech., 10(5): 152-158 (May 1992).
Mönkkönen, Jukka and Urtti, Arto, “Lipid Fusion in Oligonucleotide and Gene Delivery With Cationic Lipids,”Advanced Drug Delivery Systems,34(1):37-49 (1998).
Spivak, David A., and Shea, Kenneth J., “Investigation into the Scope and Limitations of Molecular Imprinting With DNA Molecules,”Analytica Chimica Acta,435: 65-74 (2001).
Ravikumar, Vasulinga T., et al., “Use of 2-Diphenylmethylsilylethyl (DPSE) Protecting Group on Oligonucleotide, Synthesis Via Phosphoramidite Approach,”Bioorganic&Medicinal Chem. Letters,3(12): 2637-2640 (1993), abstract.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acid-based compounds and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid-based compounds and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid-based compounds and methods of use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3872885

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.