Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-25
2007-12-25
Barts, Samuel (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
11331344
ABSTRACT:
N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover et al.
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: H725 (1990-01-01), Gordon
patent: 4963530 (1990-10-01), Hemmie et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5643924 (1997-07-01), Talley et al.
patent: 5648364 (1997-07-01), Talley et al.
patent: 5756534 (1998-05-01), Talley et al.
patent: 5948790 (1999-09-01), Talley et al.
patent: 6180646 (2001-01-01), Talley et al.
patent: 6506759 (2003-01-01), Talley et al.
patent: 6762187 (2004-07-01), Talley et al.
patent: 79823 (1988-04-01), None
patent: 104 041 (1984-03-01), None
patent: 114 993 (1984-08-01), None
patent: 264795 (1986-10-01), None
patent: 223437 (1987-05-01), None
patent: 337714 (1989-10-01), None
patent: 342541 (1989-11-01), None
patent: 346847 (1989-12-01), None
patent: 356223 (1990-02-01), None
patent: 389898 (1990-10-01), None
patent: 393445 (1990-10-01), None
patent: 393457 (1990-10-01), None
patent: 480711 (1990-10-01), None
patent: 402646 (1990-12-01), None
patent: 480624 (1992-04-01), None
patent: 480714 (1992-04-01), None
patent: 2200115 (1988-07-01), None
patent: 2209752 (1989-05-01), None
patent: WO 84/03044 (1984-01-01), None
patent: WO 92/00750 (1992-01-01), None
A. Sali et al., “High Resolution X-ray Diffraction Study of the Complex between Endothiapepsin and an Oligopeptide Inhibitor: The Analysis of the Inhibitor Binding and Description of the Rigid Shift in the Enzyme”, The EMBO Journal, vol. 8, No. 8, pp. 2179-2188 (Oxford, GB 1989).
Drugs of the Future, 1991, 16(3), pp. 210-212.
Nature, No. 6130, Aug. 6-12, 1987, p. 482, vol. 328.
V. J. Hunby et al., Pept. Struct. Funct. Proc. Am. Pept. Sym, 8thed., 1983, pp. 511-520.
Roberts et al., Rational design of peptide-based inhibitors, Science, 248, 358 (1990).
Erickson et al., Design activity and 2.8 Å crystal structure of a C2 Symmetric Inhibitor Compexed to HIV-1 Protease, Science, 249, 527 (1990).
Meek et al, Inhibition of HIV-1 protease in infected T-lymphocytes by synethetic peptide analogues, Nature, 343, 90 (1990).
McQuade et al., A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation, Science, 247, 454 (1990).
Clare Michael
DeCrescenzo Gary A.
Freskos John N.
Getman Daniel P.
Heintz Robert M.
Barts Samuel
Pharmacia Corporation
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