Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-02-13
2007-02-13
Jiang, Shaojia Anna (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S022100, C536S024500, C536S025600, C514S042000, C514S043000, C514S04400A, C514S045000, C514S048000, C514S049000, C514S052000, C514S885000, C424S001110, C424S001730, C424S001770, C424S009810, C424S278100, C424S280100
Reexamination Certificate
active
10365834
ABSTRACT:
The invention provides compounds having increased or reduced immunostimulatory effect, said compounds comprising a CpG dinucleotide and an immunomodulatory moiety wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the immunomodulatorv moiety.
REFERENCES:
patent: 5663153 (1997-09-01), Hutcherson et al.
patent: 5719271 (1998-02-01), Cook et al.
patent: 5801154 (1998-09-01), Baracchini et al.
patent: WO 97/33992 (1997-09-01), None
patent: WO 98/49288 (1998-11-01), None
patent: WO 01/12804 (2001-02-01), None
Clivio et al., “Synthesis and Purification of Oligonucleotides Containing Sulfur Substituted Nucleobases: 4-Thiouracil, 4-Thiothymine, and 6-Mercaptopurine”, Tetrahedron Letters, vol. 33, No. 1, pp. 65-68, 1992.
McCluskie et al., The Journal of Immunology 161:4463-4466 (1998).
Zhao, Q. et al., Bioorganic & Medicinal Chemistry, “Site of Chemical Modifications in CpG Containing Phosphorothioate Oligonucleotide Modulates Its Immunostimulatory Activity”, pp. 3453-3459 (1999).
Krieg, Arthur M., Applied Antisense Oligonucleotide Technology, “Leukocyte Stimulation by Oligodeoxynucleotides”, pp. 431-448 (1998).
Kandimalla, E.R. et al., Bioorganic & Medicinal Chemistry, “Effect of chemical Modifications of Cytosine and Guanine in a CpG-Motif of Oligonucleotides: Structure-Immunostimulatory Activity Relationships”, pp. 807-813 (2001).
Ekambar, D.Y. et al., Bioorganic & Medicinal Chemistry, “Modulation of Immunostimulatory Activity of CpG Oligonucleotides by Site-Specific Deletion of Nucleobases”, pp. 2263-2267 (2001).
Khorana et al. “Studies on Polynucleotides”, J. Molec. Biol. 72:209 (1972).
Agrawal et al., “Oligodeoxynucleotides Methylphosphonates: Synthesis and Enzymic Degradation”, Tetrahedron Lett. 28(31):3539-4542 (1987).
Zon et al., “Phosphorothioate Oligonucleotides” Oligonucleotides and Analogues: A Practical Approach, pp. 87-108 (1991).
Agrawal, “Antisense Oligonucleotides and Antiviral Agents”, Trends in Biotechnology, 10:152-158 (1992).
Zon, Protocols for Oligonucleotides and Analogs, Methods in Molecular Biology, 20:165-189 (1993).
Agrawal et al., “Antisense Therapeutics: Is It as Simple as Complementary Base Recognition?” Mol. Med. Today 6:72-81 (2000).
Agrawal Sudhir
Kandimalla Ekambar R.
Idera Pharmaceuticals Inc.
Jiang Shaojia Anna
Keown & Associates
McIntosh Travis C.
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