Reaction of (di)amines in the presence of a lysine oxidase...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

Reexamination Certificate

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C435S121000, C435S128000, C435S130000, C435S135000, C435S136000, C435S146000, C435S155000, C435S156000, C435S158000, C540S609000, C544S059000, C544S170000, C544S399000, C546S248000, C548S571000, C548S950000

Reexamination Certificate

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10474601

ABSTRACT:
The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a particular embodiment, the invention is directed to methods of preparing cyclic secondary amines suitable for ultimately synthesizing piperidine-2-carboxylic acid and proline derivatives, useful, for example as thrombin inhibitors.

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