Nucleotide and amino acid sequences of asporins

Details Nucleotide and amino acid sequences of asporins Nucleotide and amino acid sequences of asporins

2007-12-04

2007-12-04

Li, Ruixiang (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

10319130

ABSTRACT:
Mouse asporin protein and nucleic acid sequences are disclosed. The protein contains a unique aspartic acid region near the N-terminus. The central domain contains ten leucine rich repeats. Sequences consistent with other class I small leucine rich repeat proteoglycans (SLRP) are also observed. Methods of use for the protein include regulating the complement system, inhibiting fibrosis formation, regulating the growth of endothelial cells and angiogenesis, regulating or inhibiting the growth of cancer cells, and regulating the functions of neuromuscular junctions.

REFERENCES:
patent: 6380362 (2002-04-01), Watson et al.
Chou, K. C., Prediction of protein signal sequences and their cleavage sites. Proteins 42 (1):136-139, Jan. 1, 2001.
Henry SP, et al., “Expression Patern and gene characterization of asporin—A newly discovered member of the leucine-rich repeat protein family,”J. Biol. Chem.; vol. 276 (15); pp. 12212-12221; Apr. 13, 2001.
The RIKEN Genome Exploration Research Group Phase II Team and FANTOM Consortium; “Functional annotation of a full-length mouse cDNA collection;”Naturevol. 409, pp. 685-690; Feb. 8, 2001.
Lorenzo, P., et al.; “Identification of Asporin—A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan,”J. Biol. Chem. vol. 276 (15), pp. 12201-12211; Apr. 13, 2001.
Yamada, S. et al., “Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene”Genevol. 275 (2), pp. 279-286; Sep. 19, 2001.
Krusious, T. and Ruoslahti, E.; “Primary Structure of an Extracellular matrix proteoglycan core protein deduced from cloned cDNA,”Proc. Natl. Acad. Sci. USA, vol. 83(20), pp. 7683-7687; Oct. 1986.
Wegrowski, Y., et al.; “The Murine Biglycan : Complete cDNA Cloning, Genomic Organization, Promoter Function, and Expression,”Genomicsvol. 30(1), pp. 8-17; Nov. 1, 1995.
Scholzen, T., et al., “The Murine Decorin—Complete cDNA Cloning, Genomic Organization, Chromosomal Assignment, and Expression During Organogenesis and Tissue Differentiation”J. Biol. Chem., vol. 269(45), pp. 28270-28281; Nov. 11, 1994.
GenBank AI006670; Jun. 12, 1998.
GenBank AI539334; Apr. 13, 1998.
GenBank AK000136; Feb. 22, 2000.
GenBank BC034888; Sep. 20, 2002.
GenBank NW—000075; Nov. 17, 2002.
GenBank AK000236; Feb. 22, 2000.
GenBank NM—025711; Jan. 7, 2002.

Affiliated with

Also associated with

Rating

Nucleotide and amino acid sequences of asporins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleotide and amino acid sequences of asporins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleotide and amino acid sequences of asporins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3869645