Bradykinin-B1 antagonists, process for their preparation and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S349100, C548S334100, C548S334500, C548S311400, C548S315100, C548S311100, C548S315400, C548S312400, C546S153000, C546S272700, C546S275100, C546S210000, C544S139000, C544S370000, C544S300000, C540S575000, C514S218000, C514S235800, C514S254050, C514S274000, C514S312000, C514S326000, C514S341000

Reexamination Certificate

active

11256573

ABSTRACT:
The present invention provides bradykinin-B1 antagonists of the formulain which A, Ar, G, Q, R1and R4are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and their salts, in particular their physiologically acceptable salts with organic or inorganic acids or bases having useful properties, their preparation, medicaments comprising the pharmacologically effective compounds, their preparation and their use.

REFERENCES:
patent: 7056937 (2006-06-01), Grant et al.
patent: 7105172 (2006-09-01), Bolla
patent: WO 03/106428 (2003-12-01), None
patent: WO 2004/054584 (2004-07-01), None
patent: WO 2004/083173 (2004-09-01), None
patent: WO 2007003411 (2007-01-01), None
Conley et al. European Journal of Pharmacology 2005, 527, 44-51.
Su, Dai-Shi et al; Discovery of a potent, non-peptide bradykinin B1 receptor antagonist; Journal of the American Chemical Society; vol. 125 No. 25, pp. 7516-7517 (2003); American Chemical Society; XP002375613.

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