Tetracyclic bicyclolides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C536S007400

Reexamination Certificate

active

11302525

ABSTRACT:
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

REFERENCES:
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patent: 6054435 (2000-04-01), Or et al.
patent: 6075133 (2000-06-01), Or et al.
patent: 6274715 (2001-08-01), Or et al.
patent: 6355620 (2002-03-01), Ma et al.
patent: 2006/0069048 (2006-03-01), Or et al.
patent: 0 559 896 (1993-09-01), None
patent: WO 93/21200 (1993-10-01), None
patent: WO 97/10251 (1997-03-01), None
patent: WO 00/78773 (2000-12-01), None
patent: WO 03/095466 (2003-11-01), None
patent: WO 03/097659 (2003-11-01), None
U.S. Appl. No. 11/008,581, filed Dec. 7, 2004, Or et al.
U.S. Appl. No. 11/324,502, filed Jan. 2, 2006, Or et al.
U.S. Appl. No. 11/302,529, filed Dec. 13, 2005, Tang et al.
Zhenkun, Ma, et al., “Novel Erythromycin Derivatives With Aryl Groups Tethered to the C-6 Position are Potent Protein Synthesis Inhibitors and Active Against Multidrug-Resistant Respiratory Pathogens,”J. Med. Chem., 44: 4137-4156 (2001).

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