Retroviral protease inhibiting compounds

Details Retroviral protease inhibiting compounds Retroviral protease inhibiting compounds

1990-05-09

1992-08-25

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546280, 546328, 546334, 546335, 546245, 546264, 544 584, 544158, 544383, 544131, 544365, 544359, 544367, 548328, 548204, 548532, 548378, 549548, 549562, 549553, 549453, 560 25, 560 26, C07D40112

Patent

active

051420562

ABSTRACT:
A retroviral protease inhibiting compound of the formula

REFERENCES:
patent: 4172094 (1979-10-01), Dybas et al.
patent: 4618619 (1986-10-01), Regel et al.
patent: 4644055 (1987-02-01), Kettner et al.
patent: 4652552 (1987-03-01), Kettner et al.
Sandstrom et al. Drugs, vol. 34, pp. 373-390, 1987.
Merik Index, p. 1283.
Mitsuya et al. Nature, vol. 325 Feb. 26, 1987 pp. 773-778.
J. Wellink, et al., Arch. Virol. 98, 1-26 (1988) "Proteases Involved in the Processing of Viral Polyproteins".
L. H. Pearl et al., Nature 328 482 (1987) "Sequence Specificity of Retroviral Proteases".
H. Mitsuya et al., Nature 325 775 (1987) "Strategies for Antiviral Therapy in AIDS".
R. Dagani, Chem. Eng. News, Nov. 23, 1987, 41-49 "The Quest for Therapy".
Moore, Biochem. Biophys. Res. Commun., 159 420 (1989) "Peptide Substrates and Inhibitors of the HIV-1 Protease".
Billich, J. Biol. Chem., 263 1790S (1988) "Synthetic Peptides as Substrates and Inhibitors of Human Imune Deficiency Virus-1 Protease".
Richards, FEBS Lett. 247 113 (1989) "Effective Blocking of HIV-1 Proteinase Activity by Characteristic Inhibitors of Aspartic Proteinases".
S. Aparao et al., Synthesis, 896 (1987) "Synthesis of Functionally Substititued x,B-Unsaturated Carbonyl Compounds".
A. Padwa et al., J. Chem. Soc. Perkin Trans I. 2639 (1988) "Alkylation Studies of 5-exo-Methylene Substituted Isoxazolidines".
M. McKervey et al., Tet. Let. 23 2509 (1982) "Regiospecific Synthesis of a-(Phenylthio)Ketones via Rhodium(II) Acetate Catalysed Addition of Thiophenol to a-Diazoketones".
M. Fujiwara et al., Chem. Abstr. 91:149446 "Silver Halide Color Photographic Materials".
C. Piantadosi et al., J. Med. Chem., 19 222 (1976) "Hypocholesterolemic Activity of 1,3-Bis(substituted phenoxy)-2-propanones".
M. Midland, et al., J. Org. Chem., 39 732 (1974) "a-Disulfide Carbonium Ions".
A. Hosomi et al., Chem. Pharm. Bull., 36 3736 (1988) "Novel Arylthiomethylation of Carbonyl Compounds Using Arylthiomethyltrimethylsilanes Catalyzed by Fluoride Ions".
K. Taniguchi et al., Chem. Abstr. 108:29541 "Thermal Recording Material".
R. Freidlina et al., Chem. Abstr. 57:16463 "Reaction of 1,1-dichloro-2-propene and Crotonaldehyde with Alkyl(Aryl) Mercaptans".
T. Morikawa, Chem. Abstr. 54:19588 "Syntheses of Cholineregic Compounds".
M. Sorokin et al., Chem. Abstr. 108:111518 "Catalysis of the Reaction of Phenyl Glycidyl Ether with Aniline by Borun Trifluoride Etherate".
G. Ostroumova, Chem. Abstr. 72:56187 "Melamine Molding Materials Modified by 1,3-di(phenylamino)-2-propanol".
T. Kamilo et al., Chem. Pharm. Bull., 31 4189 (1983) "A Novel One Step Conversion of Alcohols into Alkyl Bromides or Iodides".
T. Takeda et al., Bull Chem. Soc. Jpn. 57 1863 (1984) "Preparation and Reaction of 1-Methylthio-and phenylthio)-vinyllithium Reagents".
S. Kukalenko et al., Chem. Abstr. 78:71621 "Reaction of Chlorohydrin Ethers with Amines, Phenols, Thiophenols, and Carboxylic Acids".
K. Ito et al., Chem. Pharm. Bull., 27 1691 (197

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