Computational model, method, and system for...

Details Computational model, method, and system for... Computational model, method, and system for...

2007-10-23

2007-10-23

Moran, Marjorie A. (Department: 1631)

Data processing: structural design, modeling, simulation, and em

Modeling by mathematical expression

C702S019000

Reexamination Certificate

active

10338559

ABSTRACT:
A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.

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Iliadis et al. (Computers and Biomedical Research (2000) vol. 33, pp. 211-226).

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