Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Reexamination Certificate
2007-10-23
2007-10-23
Richter, Johann (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
C556S418000, C556S420000, C548S955000, C546S014000
Reexamination Certificate
active
11120483
ABSTRACT:
The present invention provides a silane molecule which combines pre-activated and protein-resistant functionalities in one molecule; the molecule has a general formula:in-line-formulae description="In-line Formulae" end="lead"?A-(CH2)n—(O[CH2]t)m—(CH2)v—Y (1)in-line-formulae description="In-line Formulae" end="tail"?wherein A is a functional group for binding to a substrate and Y is a functional group for binding to biomolecules. The invention furthermore provides a method for the synthesis of such a silane molecule and a method for depositing a monolayer of such silane molecules onto a substrate. Such a monolayer of silane molecules may be used in biosensors, DNA/protein micro-arrays or other sensor applications. For further lowering the protein binding to the surface of the biosensor, the monolayer may furthermore comprise second silane molecules with formula:in-line-formulae description="In-line Formulae" end="lead"?B—(CH2)o—(OCH2CH2)r—Z. (4)in-line-formulae description="In-line Formulae" end="tail"?
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Jans Karolien
Laureyn Wim
Palma Randy De
Interuniversitair Microelektronica Centrum (IMEC)
Knobbe Martens Olson & Bear LLP
Nwaonicha Chukwuma
Richter Johann
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