Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2007-02-20
2007-02-20
Wells, Nikita (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000, C250S282000
Reexamination Certificate
active
11244626
ABSTRACT:
A MALDI/LDI source is disclosed that includes an ion optical device and beam-focusing optics disposed on opposite sides of a sample support that is at least locally transparent in a region underlying the sample to allow transmission of a radiation beam therethrough. A laser or other radiation source, located adjacent a rear surface of the sample support, emits a beam of radiation that is focused by the beam focusing optics and traverses the transparent region of the sample support to impinge on the sample. Ions produced by irradiation of the sample are collected by an ion optical device located adjacent the front surface of the sample support. By locating the ion optical device and beam-focusing optics on opposite sides of the sample support, short focal length beam-focusing optics may be utilized, thereby facilitating smaller beam spot sizes. This may be particularly useful for mass spectral tissue imaging and other applications where high spatial resolution analysis of a differentiated sample is desirable.
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Souw Bernard
Thermo Finnigan LLC
Upham Sharon
Wells Nikita
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