Proteomic screening for redox state dependent...

Details Proteomic screening for redox state dependent... Proteomic screening for redox state dependent...

2007-06-12

2007-06-12

Vogel, Nancy (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007310, C435S325000, C435S375000

Reexamination Certificate

active

10378419

ABSTRACT:
This invention provides a modified yeast two-hybrid system in order to identify NO-dependent protein-protein interactions. Bait proteins implicated in apoptotic signaling pathways were used to identify NO-dependent interactions. The physiological relevance of these interactions is demonstrated by their occurrence and dependence on endogenous NO in mammalian cells, and by the functional interrelatedness of bait and prey.

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