Medicament for prevention and/or therapy of arterial wall...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S404000, C514S443000, C514S469000, C514S471000, C514S412000, C514S405000

Reexamination Certificate

active

10643404

ABSTRACT:
An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided a method for prevention and/or therapy of arterial wall injury which comprises a step of administering the pyrazolone derivative represented by the following formula (I) or the physiologically acceptable salt thereof, or the hydrate or solvate thereof in a preventively or therapeutically effective amount to mammals including humans:wherein R1represents a hydrogen atom, an aryl group, an alkyl group, or an alkoxycarbonylalkyl group; R2represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group or a hydroxyalkyl group; or R1and R2are combined with each other to represent an alkylene group; and R3represents a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, a benzyl group, a naphthyl group, a phenyl group, or a phenyl group substituted with 1 to 3 substituents selected from the group consisting of an alkyl group, an alkoxy group, a hydroxyalkyl group, an alkoxycarbonyl group, an alkylmercapto group, an alkylamino group, a dialkylamino group, a halogen atom, a trifluoromethyl group, a carboxyl group, a cyano group, a hydroxyl group, a nitro group, an amino group and an acetamide group.

REFERENCES:
patent: 4857542 (1989-08-01), Nishi et al.
patent: RE35801 (1998-05-01), Nishi et al.
patent: 1386606 (2004-02-01), None
patent: 09052831 (1997-02-01), None
patent: WO 0224667 (2002-03-01), None

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