Synthesis of...

Details Synthesis of... Synthesis of...

2007-12-25

2007-12-25

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S253000

Reexamination Certificate

active

11328966

ABSTRACT:
Provided is a novel method of making 2-butyl-3-[[2′(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.

REFERENCES:
patent: 5270317 (1993-12-01), Bernhart et al.
patent: 5541209 (1996-07-01), Spinale
patent: 5559233 (1996-09-01), Bernhart et al.
patent: 5629331 (1997-05-01), Caron et al.
patent: 6800761 (2004-10-01), Franc et al.
patent: 7008959 (2006-03-01), Franc et al.
patent: 7019148 (2006-03-01), Nisnevich et al.
patent: 7038060 (2006-05-01), Dolitzky et al.
patent: 2004/0192713 (2004-09-01), Nisnevich et al.
patent: 2005/0032862 (2005-02-01), Franc et al.
patent: 2005/0176794 (2005-08-01), Dolitzky et al.
patent: WO 2004/007482 (2004-01-01), None
patent: WO 99/06398 (1999-02-01), None
Le Bourdonnec, B., et al., “Synthesis and Pharmacological Evolution of New Pyrazolidine-3,5-diones as AT1 Angiotensin II Receptor Antagonists”,J. Med.Chem., vol. 43(14), pp. 2685-2697 (2000), at p. 2687, Scheme 2, “reaction b” with compound 19.

Affiliated with

Also associated with

Rating

Synthesis of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3850990