Growth factor therapy mobilization of stem cells into the...

Details Growth factor therapy mobilization of stem cells into the... Growth factor therapy mobilization of stem cells into the...

2007-11-06

2007-11-06

Romeo, David S (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S093210

Reexamination Certificate

active

11029449

ABSTRACT:
Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA and VEGF165; (ii) isolating the peripheral blood stem cells (PBSC) by apheresis; and (iii) injecting the PBSC into a patient suffering from chronic heart disease. Alternatively, gene therapy is used for the induction of the stem cells into the peripheral blood, wherein the gene therapy formulation comprises AD5FGF-4 or VEGF165 plasmid DNA. Additionally, the progress of the treatment of the chronic heart disease is monitored by using an echocardiogram unit.

REFERENCES:
patent: 5932540 (1999-08-01), Hu et al.
patent: 6352971 (2002-03-01), Deisher et al.
patent: 6482406 (2002-11-01), Stewart
patent: 6608182 (2003-08-01), Rosen et al.
patent: 6673604 (2004-01-01), Edge
patent: 6716626 (2004-04-01), Itoh et al.
patent: 6734285 (2004-05-01), Hu et al.
patent: 6775574 (2004-08-01), Soykan et al.
patent: 6852533 (2005-02-01), Rafii et al.
patent: 7166280 (2007-01-01), Franco
patent: 2002/0090722 (2002-07-01), Dominko et al.
patent: 2002/0142457 (2002-10-01), Umezawa
patent: 2002/0172663 (2002-11-01), Palasis
patent: 2003/0022367 (2003-01-01), Xu
patent: 2003/0023995 (2003-01-01), Benezra
patent: 2003/0082148 (2003-05-01), Ludwig et al.
patent: 2003/0103951 (2003-06-01), Pittenger et al.
patent: 2003/0199464 (2003-10-01), Itescu
patent: 2003/0211994 (2003-11-01), Li et al.
patent: 2003/0219898 (2003-11-01), Sugaya et al.
patent: 2004/0018174 (2004-01-01), Palasis
patent: 2004/0028658 (2004-02-01), Faustman
patent: 2004/0033214 (2004-02-01), Young et al.
patent: 2004/0048375 (2004-03-01), Alt
patent: 2004/0071665 (2004-04-01), Xiao et al.
patent: 2004/0071687 (2004-04-01), Rafii et al.
patent: 2004/0096936 (2004-05-01), Deisher et al.
patent: 2004/0107453 (2004-06-01), Furcht et al.
patent: 2004/0131585 (2004-07-01), Itescu
patent: 2004/0131601 (2004-07-01), Epstein et al.
patent: 2004/0161412 (2004-08-01), Penn et al.
patent: 2004/0161421 (2004-08-01), Komowski et al.
patent: 2005/0026220 (2005-02-01), Rafii et al.
patent: 2005/0069527 (2005-03-01), Laughlin et al.
Mathur, A; Martin, JF, “Stem Cells And Repair Of The Heart”,LancetJul. 10, 2004;364 (9429): 183-192.
Fijnvandraat, AC; Morman, AF, “Stem Cells: biology and possible application to myocardial infarct”,Ned Tijdschr. GeneeskdJun. 12, 2004: 148 (24): 1186-91.
Aschermann, M; Horak, J; Linhard A; Aschermann, O, “Use Of Stem Cells For Myocardial Regeneration”,Cas Lek Cesk.2004; 143 (2): 71-4.
Murry, CE; Soonpaa MH et al., “Haematopoietic Stem Cells Do Not Transdifferentiate Into Cardiac Myocytes In Myocardial Infarcts”,NatureApr. 8, 2004; 428 (6983); 664-8. Epub Mar. 21, 2004.
Fraser JK; Schreiber RE et al., “Adult Stem Cell Therapy For The Heart”,International Journal of Biochemistry And Cell BiologyApr. 2004; 36 (4): 658-66.
Strauer, BE; Brehm M et al., “Stem Cell Therapy In Acute Myocardial Infarction”,Med Klin(Munich). Dec. 15, 2003: 98 Supplement 2: 14-8.
Masino, AM; Gallardo, TD; Wilcox, CA, et al., “Transcriptional Regulation of Cardian Progenitor Cell Populations”,Circulation Research95: 389-397, Aug. 2004.
Melo, LG; Pachori, AS, et al., “Gene and Cell-Based Therapies For Heart Disease”,FASEB J.Apr. 2004; 18 (6): 648-63.

Affiliated with

Also associated with

Rating

Growth factor therapy mobilization of stem cells into the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Growth factor therapy mobilization of stem cells into the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Growth factor therapy mobilization of stem cells into the... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3843819