Synthesis of mitomycin and its analogs

Details Synthesis of mitomycin and its analogs Synthesis of mitomycin and its analogs

1994-03-14

1996-06-04

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548421, 548423, 548428, 544 63, 544 72, C07D48702, C07D48714

Patent

active

055234119

ABSTRACT:
The present invention relates to the synthesis of mitomycin and analogs thereof that are useful as anticancer antibiotics. The invention further relates to analogs of mitomycin, which can be prepared according to the methods of synthesis provided. The synthetic method of the invention provides for reacting a derivitized indole with a dialkylvinylsulfonium salt to yield a tricyclic skeleton having the precursors of the fourth ring in one step, followed by an oxidation step or steps to close the fourth ring and prepare mitomycin or a related compound.

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