Nucleic acid fragment encoding an NRPS for the biosynthesis...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound

Reexamination Certificate

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C435S252300, C435S252330, C435S252340, C435S252350, C435S320100, C536S023200, C536S023100, C536S023700

Reexamination Certificate

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11481907

ABSTRACT:
Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin fromStreptomyces refuineussubsp.thermotolerans. The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in the biosynthesis of anthramycin.

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