Molecules of the pyrin domain protein family and uses thereof

Details Molecules of the pyrin domain protein family and uses thereof Molecules of the pyrin domain protein family and uses thereof

2007-11-27

2007-11-27

Canella, Karen A. (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100, C435S007200, C435S007800

Reexamination Certificate

active

10127516

ABSTRACT:
Diagnostic, screening and therapeutic methods utilizing NBS-1 and PYRIN-1 are disclosed. The methods take advantage of the interactions between NBS-1 or PYRIN-1 and various proteins involved in apoptotic and inflammatory signaling pathways. Also disclosed are methods for identifying modulators of ASC and NF-κB.

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