Complexes and compositions for magnetic resonance imaging and us

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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436173, 436806, 1286534, 514492, 514502, 514836, 534 13, 534 16, 556 45, 556 57, 556110, 556138, G01N 2400, G01N 3100, A61K 3128, C07F 500

Patent

active

051417405

ABSTRACT:
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

REFERENCES:
patent: 4647447 (1987-03-01), Gries et al.
patent: 4687658 (1987-08-01), Quay
patent: 4687659 (1987-08-01), Quay
patent: 4826673 (1989-05-01), Dean et al.
Turowski, P. N. et al. Inorganic Chemistry 27(3):474-481 (1988).

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