Methods of preparing pro-liposome dispersions and aerosols

Details Methods of preparing pro-liposome dispersions and aerosols Methods of preparing pro-liposome dispersions and aerosols

1991-06-24

1992-08-25

Stoll, Robert L.

Compositions

Inorganic luminescent compositions

Tungsten containing

424450, 424 45, 424 40, 424 47, 264 41, 4272133, A61K 912, A61K 9127, B01J 1302

Patent

active

051416743

ABSTRACT:
Compositions that are sprayable or that are in the form of discrete particles and that contain a lipid and a biologically active compound in the form of a micronized powder combine a high initial entrapment of the active compound in the membrane lipid with sustained release at the site of application as indicated by in-vitro and in-vivo tests. In a first form pro-liposomes are prepared by spraying under pressure through a nozzle a single composition comprising at least one volatile liquid propellant, at least one membrane lipid that is at least partly dissolved or dispersed in the propellant and at least one biologically active compound that is present in dispersion in the propellant and/or the lipid, the composition being free from other solvent for the lipid. In a second form the membrane lipid and the biologically active compound are minor components of micronized solid particles whose major component is a physiologically acceptable solid carrier.

REFERENCES:
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4370349 (1983-01-01), Evans et al.
patent: 4508703 (1985-04-01), Redziniak et al.
patent: 4830858 (1989-05-01), Payne et al.
patent: 5004611 (1991-04-01), Leigh
patent: 5049388 (1991-09-01), Knight et al.
patent: 5053217 (1991-10-01), Leigh

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