Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-11-06
2007-11-06
Lewis, Patrick (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S045000, C514S046000, C536S026210, C536S026220, C536S026230, C536S026240, C536S026500, C536S026700, C536S026710, C424S001570, C424S001730, C424S001770, C424S137100, C424S141100, C424S175100, C424S184100
Reexamination Certificate
active
10416388
ABSTRACT:
Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
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Imai, S., et al., “Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase”, Nature, vol. 403: pp. 795-800, (2000).
Smith, J.S., et al., “A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family”, Proc. Natl. Acad. Sci. U.S.A., vol. 97: pp. 6658-6663 (2000).
Frye, R.A., “Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity”, Biochem. Biophys. Res. Commun., vol. 260: pp. 273-279 (1999).
Denu John M.
Tanner Kirk G.
Dann Dorfman Herrell & Skillman P.C.
Lewis Patrick
Netter Robert C.
Rigaut Kathleen D.
Wisconson Alumni Research Foundation
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