Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-29
2007-05-29
Foley, Shanon (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024330, C435S091200, C435S091330
Reexamination Certificate
active
09810501
ABSTRACT:
The present invention provides a purified preparation containing a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), proteins at least 80% but less than 100% homologous with those encoded by one or more of ORF 2, ORF 3, ORF 4 and ORF 5 of an Iowa strain of PRRSV, proteins at least 97% but less than 100% homologous with proteins encoded by one or both of ORF 6 and ORF 7 of an Iowa strain of PRRSV, antigenic regions of such proteins which are at least 5 amino acids in length and which effectively stimulate immunological protection in a porcine host against a subsequent challenge with a PRRSV isolate, and combinations thereof, in which amino acids non-essential for antigenicity may be conservatively substituted. The present invention also concerns a polypeptide encoded by such a polynucleic acid; a vaccine comprising an effective amount of such a polynucleic acid or protein; antibodies which specifically bind to such a polynucleic acid or protein; methods of producing the same; and methods of raising an effective immunological response against a PRRSV, treating a pig infected by a PRRSV, and detecting a PRRSV.
REFERENCES:
patent: 5213795 (1993-05-01), Carlson et al.
patent: 5419907 (1995-05-01), Paul et al.
patent: 5476778 (1995-12-01), Chladek et al.
patent: 5510258 (1996-04-01), Sanderson et al.
patent: 5587164 (1996-12-01), Sanderson et al.
patent: 5597721 (1997-01-01), Brun et al.
patent: 5620691 (1997-04-01), Wensvoort et al.
patent: 5674500 (1997-10-01), Peeters et al.
patent: 5677429 (1997-10-01), Benfield
patent: 5683865 (1997-11-01), Collins et al.
patent: 5695766 (1997-12-01), Paul et al.
patent: 5698203 (1997-12-01), Visser et al.
patent: 5789388 (1998-08-01), Visser et al.
patent: 5840563 (1998-11-01), Chladek et al.
patent: 5846805 (1998-12-01), Collins et al.
patent: 5858729 (1999-01-01), Van Woensel et al.
patent: 5866401 (1999-02-01), Hesse
patent: 5888513 (1999-03-01), Plana Duran et al.
patent: 5910310 (1999-06-01), Heinen et al.
patent: 5925359 (1999-07-01), Van Woensel et al.
patent: 5976537 (1999-11-01), Mengeling et al.
patent: 5989563 (1999-11-01), Chladek et al.
patent: 5998601 (1999-12-01), Murtaugh et al.
patent: 6001370 (1999-12-01), Burch et al.
patent: 6015663 (2000-01-01), Wesley et al.
patent: 6197310 (2001-03-01), Wensvoort et al.
patent: 6455245 (2002-09-01), Wensvoort et al.
patent: 6495138 (2002-12-01), van Nieuwstadt et al.
patent: 2076744 (1992-08-01), None
patent: 0 595 436 (1994-05-01), None
patent: 2282811 (1995-04-01), None
patent: WO 92/21375 (1992-12-01), None
patent: WO 93/03760 (1993-03-01), None
patent: WO 93/06211 (1993-04-01), None
patent: WO 93/07898 (1993-04-01), None
patent: WO 94/18311 (1994-08-01), None
patent: WO 95/31550 (1995-11-01), None
patent: WO 96/04010 (1996-02-01), None
patent: 96 06619 (1996-03-01), None
patent: WO 96/40932 (1996-12-01), None
Key et al. Veterinary Microbiology. 2001; 83: 249-263.
H. Mardassi et al., “Molecular analysis of the ORFs 3 to 7 of porcine reproductive and respiratory syndrome virus, Québec reference strain,” Arch. Virol., 1995, pp. 1405-1418, vol. 140, Springer-Verlag, Austria.
R.W. Wills et al., “Transmission of PRRS Virus by Contact vs Airborne Exposures”, Final Report of a grant, 1995, pp. 103-108, National Pork Producers Council, Des Moines, Iowa.
Samir Mounir et al, Expression and Characterization of PRRSV Envelope and ns4 Proteins, American Society for Virology, Annul Meeting, Jul. 9-12, 1994, Madison, WI.
Helmi Mardassi et al, Identification of Major Differences in the Nucleocapsid Protein Genes of a Quebec Strain and European Strains of Porcine Reproductive and Respiratory Syndrome Virus, Journal of General Virology, vol. 75, pp. 681-685 (1994).
H.S. Kim et al, Enhanced Replication of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus in a Homogeneous Subpopulation of MA-104 Cell Line, Arch. Virol., vol. 133, pp. 477-483 (1993).
Janneke J.M. Meulenberg et al., “Lelystad Virus, the Causative Agent of Porcine Epidemic Abortion and Respiratory Syndrome (PEARS), is Related to LDV and EAV”, Virology, vol. 192, No. 1, pp. 62-72, 1993.
Kuchler, Biochemical Methods in Cell Culture and Virology, Dowden, Hutchinson & Ross, Inc. (Stroudsburg, PA), p. 4-10 (1977).
Swenson et al., JAVMA, 204: 1943-1948 (1994).
A.A.S.P., Sep./Oct. (1991), pp. 7-11.
The Veterinary Record, Feb. 1, 1992, pp. 87-89.
The Veterinary Record, Nov. 30, 1991. p. 495-496.
The Veterinary Record, Oct. 26, 1991, p. 370.
The Veterinary Record, Oct. 19, 1991, pp. 367-368.
The Veterinary Record, Aug. 3, 1991, pp. 102-103.
The Veterinary Record, Jul. 6, 1991.
The Veterinary Record, Jun. 22, 1991, pp. 578.
The Veterinary Record, Jun. 15, 1991, p. 574.
The Veterinary Record, Jun. 8, 1991, p. 536.
The Veterinary Record, Jun. 1, 1991, p. 511.
The Veterinary Record, Mar. 2, 1991, p. 213.
Wensvoort et al, Vet. Quarterly, 13:121-130 (1991).
Wensvoort et al, Vet. Res., 24:117-124 (1993).
Paul et al, J. Clin. Vet. Med., 11:19-28 (1993).
Benfield et al, J. Vet. Diagn. Invest., 4:127-133 (1992).
Joo, PRRS: Diagnosis. Proc., Allen D. Leman Swine Conf., 20:53-55 (1993).
Kim et al, Arch. Virol., 133-477-483 (1993).
Bautista et al, J. Vet. Diagn. Invest., 5:163-165 (1993).
Conzelmann et al, Virology, 193:329-339 (1993).
Meulenberg et al, Virology, 192:62-72 (1993).
Goyal, J. Vet. Diagn. Invest., 5:656-664 (1993).
Pol et al, Veterinary Quarterly, 13:137-143 (1991).
Christianson et al, Am. J. Vet. Res., 53:485-488 (1992).
Collins et al, J. Vet. Diagn. Invest., 4:117-126 (1992).
Collins et al, Proc. Allen D. Leman Conference, pp. 47-48 (1993).
Murtaugh, Proc. Allen D. Leman Conference, pp. 43-45 (1993).
Mardassi et al, Abstract. Conf. Res. Workers in Animal Dis., Chicago, Illinois, p. 43 (1993).
Mardassi et al, J. Gen. Virol, 75:681-685 (1994).
Wensvoort et al, J. Vet. Diagn. Invest., 4:134-138 (1992).
Bautista et al, J. Vet. Diagn. Invest., 5:612-614 (1993).
Stevenson et al, J. Vet. Diagn. Invest., 5:432-434 (1993).
Animal Pharm., 264:11 (Nov. 13, 1992).
Vaughn et al, J. Clin. Micro., 32:1809-1812 (1994).
Hill et al, Am. Assoc. Swine Practitioner Newsletter., 4:47 (1992).
Hill et al, Proceedings Mystery Swine Disease Committee Meeting, Denver, Colorado., pp. 29-31 (1990).
Loula, Agri-Practice., 12:23-34 (1991).
Paton et al, Vet. Rec., 128:617 (1991).
Blaha, Proc. Am. Assoc. Swine Practitioners, pp. 313-315 (1993).
Collins et al, Proc., Minnesota Swine Conference for Veterinarians, pp. 200-205 (1991).
Woolen et al, J. Am. Vet. Med. Assoc., 197:600-601 (1990).
Plagemann, Proc. Am. Assoc. Swine Practitioners., 4:8-15 (1992).
Plagemann and Moennig, Adv. Virus Res., 41:99-192 (1992).
Spaan et al, J. Gen. Virol., 69:2939-2952 (1988).
Lai, Annu. Rev. Microbiol., 44;303-333 (1990).
Snijder et al, Nucleic Acid Res., 18:4535-4542 (1990).
Halbur et al, Proc. Central Veterinary Conference., pp. 750-759 (1993).
Nelson et al, J. Clin. Microbiol., 31:3184-3189 (1993).
Dalziel et al, J. Virol., 59-463-471 (1986).
Fleming et al, J. Virol., 58:869-875 (1986).
Fiscus et al, J. Virol., 61:2607-2613 (1987).
Parker et al, Virology., 173:664-673 (1989).
Laude et al, Vet. Res., 24:125-150 (1993).
Rasschaert et al, J. Gen. Virol., 71:2599-2607 (1990).
Magar et al, Can J. Vet. Res., 57:300-304 (1993).
Halbur et al, Proc. Am. Assoc. Swine Pract., 343-350 (1993).
Bautists et al, American Association of Swine Practitioners Newletter, 4:32 (1992).
Kohler et al, Nature, 256:495-497 (1975).
Godney et al, Virology, 177:768-771.
Hooper et al, J. Vet. Diagn. Invest., 6:13-25 (1994).
Koonin et al, Critical Rev. Biochem. Mol. Biol., 28:375-430 (1993).
Lai, Microbiol. Rev., 56:61-79 (1992).
Hahn et al, Proc. Natl. Acad. Sci. USA, 85:5997-6001 (1988).
Godeny et al, Virology, 194:585-596 (1993).
Mardassi, J. Gen. Virol., 75:681-685 (1994).
Kuo et al, Virus Res., 23:55-72 (1992).
Chen, J. Gen. Virol., 74:643-660 (1993).
Meng, J. Vet. Diagn. Invest.,
Halbur Patrick
Lum Melissa A.
Meng Xiang-Jin
Morozov Igor
Paul Prem S.
Bingham & McCutchen LLP
Crane Sharon E.
Foley Shanon
Iowa State University & Research Foundation, Inc.
Wyeth Holdings Corporation
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