Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-01-09
2007-01-09
Jiang, Shaojia A. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S123000, C544S295000, C544S320000, C544S060000
Reexamination Certificate
active
10492547
ABSTRACT:
The invention provides novel pyrimidone compounds exhibiting excellent antagonism against adenosine receptors (A1, A2A, and A2Breceptors), particularly, compounds represented by the general formula (1), salts thereof, or solvates of both: (1) wherein R1and R2are each independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C3-8cycloalkenyl, a 5- to 14-membered nonaromatic heterocyclic group, a C6-14aromatic hydrocarbon group, a 5- to 14-membered aromatic heterocyclic group, C1-6acyl, or C1-6alkylsulfonyl; R3is hydrogen, C1-6alkyl, C2-6alkenyl, or C2-6alkynyl; R4is a C6-14aromatic hydrocarbon group; a 5- to 14-membered aromatic heterocyclic group, or a 5- to 14-membered nonaromatic heterocyclic group having at least one unsaturated bond; and R5is a C6-14aromatic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group (with the proviso that every group except hydrogen may be substituted).
REFERENCES:
patent: 4725600 (1988-02-01), Takaya et al.
patent: 6096753 (2000-08-01), Spohr et al.
patent: 1088053 (1994-06-01), None
patent: 0 216 247 (1987-04-01), None
patent: 1136482 (2001-09-01), None
patent: 1136486 (2001-09-01), None
patent: 3-173889 (1991-07-01), None
patent: 4271770 (1992-09-01), None
patent: 6-211669 (1994-08-01), None
patent: 11-263789 (1999-09-01), None
patent: WO 94/16702 (1994-08-01), None
patent: WO 97/33883 (1997-09-01), None
patent: WO 98/24780 (1998-06-01), None
patent: WO 98/24780 (1998-06-01), None
patent: WO 98/24782 (1998-06-01), None
patent: WO 99/35147 (1999-07-01), None
patent: WO 99/62518 (1999-12-01), None
patent: WO 99/64418 (1999-12-01), None
patent: WO-00/18758 (2000-04-01), None
patent: WO 00/24742 (2000-05-01), None
patent: WO 01/02400 (2001-01-01), None
patent: WO 01/80893 (2001-01-01), None
patent: WO-01/70727 (2001-09-01), None
Hannah et al, Bioorganic and Medicinal Chemistry, 2000, 8, 739-750.
Chemical Abstracts, vol. 77, Abstract No. 34471j.
Duncan R. Hannah et al.; Bioorganic & Medicinal Chemistry, vol. 8, No. 4, pp. 739-750, 2000.
Dietrich van Calker et al.; Journal of Neurochemistry, vol. 33, pp. 999-1003, 1979.
Robert F. Bruns et al.; Molecular Pharmacology, vol. 29, pp. 331-346, 1986.
W. Wan et al.; Journal of Neurochemistry; vol. 55, No. 5, pp. 1763-1771, 1990.
Igor Feoktistov et al.; J. Clin. Invest., vol. 96, pp. 1979-1986, 1995.
Alistair K. Dixon et al.; British Journal of Pharmacology, No. 118, pp. 1461-1468, 1996.
Julie A. Peachey et al.; Naunyn-Schmiedeberg's Arch Pharmacol., No. 359, pp. 140-146, 1999.
Makoto Kadowaki et al.; British Journal of Pharmacology, No. 129, pp. 871-876, 2000.
Maarten de Zwart et al.; Drug Development Research, No. 48, pp. 95-103, 1999.
Yong-Chul Kim et al.; J. Med. Chem., No. 43, pp. 1165-1172, 2000.
Bioorg. Med. Chem., vol. 8, No. 4, pp. 739-750 (2000).
Chemical Abstracts, vol. 77, abs. No. 34471, RN=37005-17-7, 37012-54-7.
Kadowaki et al., British Journal of Pharmacology, vol. 129, pp. 871-876 (2000).
Nitahara et al., Neuroscience, vol. 67, No. 1, pp. 159-168 (1995).
Peachey et al., Naunyn-Schmiedeberg's Arch Pharmacol., vol. 359, pp. 140-146 (1999).
Tomaru et al., European Journal of Pharmacology, vol. 264, pp. 91-94 (1994).
Christofi et al., Gastroenterology, vol. 104, pp. 1420-1429 (1993).
Suzuki et al., Jpn. J. Pharmacol., vol. 68, pp. 119-123 (1995).
Dixon et al., British Journal of Pharmacology, vol. 118, pp. 1461-1468 (1996).
Klauser et al., Pharmacology, vol. 47, Supp. 1, pp. 256-260 (1993) (Abstract).
Skulnick et al., J. Med. Chem. vol. 28, pp. 1864-1869, (1985).
Kabbe et al., Liebigs Ann. Chem., vol. 704, pp. 144-149, (1967).
Asano Osamu
Harada Hitoshi
Kabasawa Yasuhiro
Kotake Yoshihiko
Miyazawa Shuhei
Birch, Stewart, Kolasch and Birch LLP
Eisai Co. Ltd.
Jiang Shaojia A.
Krishnan Ganapathy
LandOfFree
Pyrimidone compounds and pharmaceutical compositions... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrimidone compounds and pharmaceutical compositions..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidone compounds and pharmaceutical compositions... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3817387