Chiral supports for resolution of racemates

Compositions – Absorptive – or bindive – and chemically yieldive

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210635, 210656, 210659, 252430, 252455R, 252463, 428407, 428702, B01D 1508

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active

043223109

ABSTRACT:
A composition comprising a chiral organic amine covalently linked via a carbamate, mercaptocarbamate, or urea linkage to a chain of atoms whose other terminus is covalently bound to a core support may be used as a solid phase chromatographic medium in the separation of racemic mixtures. An example is alpha-methylbenzyl amine bound through a carbamate linkage to a 3-propylsilyl group covalently bonded to an alumina support.

REFERENCES:
patent: 4111838 (1978-09-01), Schaeffer
patent: 4159966 (1979-07-01), Roberts
Henderson et al., Nature, vol. 141, (May 21, 1938), pp. 917-918.
Henderson et al., Nature, vol. 142, (Jul. 23, 1938), pp. 162-163.
Blaschke et al., Chemische Berichto, vol. 109, (1976), pp. 1967-1975.
Baczue et al., J. of Chromatography, vol. 60, (1971), pp. 351-361.

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