Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-06-19
2007-06-19
Kwon, Brian (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
54
Reexamination Certificate
active
10627372
ABSTRACT:
Methods are provided for treating or prophylactically preventing metabolic disorders in humans without causing, promoting, or aggravating fluid retention, peripheral edema, pulmonary edema, or congestive heart failure, by administration of a therapeutically effective amount of a compound sufficient to partially or fully activate peroxisome proliferator activated receptors (PPARs) and partially or fully inhibit, antagonize or block the activity of angiotensin II type 1 receptors. Metabolic disorders that can be treated or prevented include but are not limited to type 2 diabetes, the metabolic syndrome, prediabetes, and other insulin resistance syndromes. Compounds are provided that antagonize or block the angiotensin II type 1 (AT1) receptor, function as partial or full activators of peroxisome proliferator activated receptors (PPARs), can be used to treat or prevent diseases known to be treatable or preventable by PPAR activators and were not previously recognized to be therapeutic targets for angiotensin II receptor antagonists.
REFERENCES:
patent: 5128356 (1992-07-01), Naka et al.
patent: 5162326 (1992-11-01), Naka et al.
patent: 5196444 (1993-03-01), Naka et al.
patent: 5243054 (1993-09-01), Naka et al.
patent: 5250554 (1993-10-01), Naka et al.
patent: 5284661 (1994-02-01), Morimoto et al.
patent: 5328919 (1994-07-01), Naka et al.
patent: 5354766 (1994-10-01), Naka et al.
patent: 5389641 (1995-02-01), Naka et al.
patent: 5401764 (1995-03-01), Naka et al.
patent: 5463073 (1995-10-01), Takehiko et al.
patent: 5496835 (1996-03-01), Kubo et al.
patent: 5500427 (1996-03-01), Kubo et al.
patent: 5506245 (1996-04-01), Regnier et al.
patent: 5541229 (1996-07-01), Narr et al.
patent: 5565469 (1996-10-01), Mihm et al.
patent: 5583141 (1996-12-01), Naka et al.
patent: 5587393 (1996-12-01), Narr et al.
patent: 5591762 (1997-01-01), Hauel et al.
patent: 5594003 (1997-01-01), Hauel et al.
patent: 5602127 (1997-02-01), Hauel et al.
patent: 5614519 (1997-03-01), Hauel et al.
patent: 5639773 (1997-06-01), Kubo et al.
patent: 5663186 (1997-09-01), Nelson et al.
patent: 5663187 (1997-09-01), Nelson et al.
patent: 5684029 (1997-11-01), Narr et al.
patent: 5693651 (1997-12-01), Nomura et al.
patent: 5703110 (1997-12-01), Naka et al.
patent: 5705517 (1998-01-01), Naka et al.
patent: 5736555 (1998-04-01), Naka et al.
patent: 5741803 (1998-04-01), Pool et al.
patent: 5801173 (1998-09-01), Lohray et al.
patent: 5811439 (1998-09-01), Ogawa et al.
patent: 5817075 (1998-10-01), Giungo
patent: 5824694 (1998-10-01), Kurtz et al.
patent: 5827865 (1998-10-01), Haigh et al.
patent: 5834501 (1998-11-01), Fujita et al.
patent: 5843172 (1998-12-01), Yan
patent: 5843970 (1998-12-01), Pershadsingh et al.
patent: 5847008 (1998-12-01), Doebber et al.
patent: 5859051 (1999-01-01), Adams et al.
patent: 5864043 (1999-01-01), Narr et al.
patent: 5868728 (1999-02-01), Giungo et al.
patent: 5869495 (1999-02-01), Haigh et al.
patent: 5883111 (1999-03-01), Naka et al.
patent: 5885997 (1999-03-01), Lohray et al.
patent: 5886014 (1999-03-01), Fujita et al.
patent: 5889025 (1999-03-01), Lohray et al.
patent: 5889032 (1999-03-01), Lohray et al.
patent: 5902726 (1999-05-01), Kliewer et al.
patent: 5910592 (1999-06-01), Pool et al.
patent: 5919782 (1999-07-01), Lohray et al.
patent: 5925656 (1999-07-01), Kallam et al.
patent: 5932601 (1999-08-01), Sohda et al.
patent: 5939442 (1999-08-01), Evans et al.
patent: 5952356 (1999-09-01), Ikeda et al.
patent: 5952509 (1999-09-01), Saito et al.
patent: 5958942 (1999-09-01), Takatani et al.
patent: 5958961 (1999-09-01), Inada et al.
patent: 5962470 (1999-10-01), Fujita et al.
patent: 5962491 (1999-10-01), Naka et al.
patent: 5965584 (1999-10-01), Ikeda et al.
patent: 5968589 (1999-10-01), Murakami
patent: 5972959 (1999-10-01), Yanagisawa et al.
patent: 5972970 (1999-10-01), Sohda et al.
patent: 5977365 (1999-11-01), Fujita et al.
patent: 5985884 (1999-11-01), Lohray et al.
patent: 5990139 (1999-11-01), Yano et al.
patent: 6004989 (1999-12-01), Naka et al.
patent: 6008237 (1999-12-01), Sahoo et al.
patent: 6011031 (2000-01-01), Lohray et al.
patent: 6011036 (2000-01-01), Lohray et al.
patent: RE36575 (2000-02-01), Meguro et al.
patent: 6020382 (2000-02-01), Doebber et al.
patent: 6022897 (2000-02-01), Evans et al.
patent: 6028088 (2000-02-01), Pershadsingh et al.
patent: 6087384 (2000-07-01), Matsui et al.
patent: 6087385 (2000-07-01), Pershadsingh et al.
patent: 6090836 (2000-07-01), Adams et al.
patent: 6090839 (2000-07-01), Adams et al.
patent: 6100252 (2000-08-01), Naka et al.
patent: 6100403 (2000-08-01), Saito et al.
patent: 6103742 (2000-08-01), Ikeda et al.
patent: 6113907 (2000-09-01), Khwaja et al.
patent: 6117893 (2000-09-01), Fujita et al.
patent: 6150371 (2000-11-01), Fujiwara et al.
patent: 6160000 (2000-12-01), Adams et al.
patent: 6200995 (2001-03-01), De la Brouse-Elwood et al.
patent: 6228874 (2001-05-01), Inada et al.
patent: 6232334 (2001-05-01), Naka et al.
patent: 6329415 (2001-12-01), Cirillo et al.
patent: 6333325 (2001-12-01), Cirillo et al.
patent: 6348481 (2002-02-01), Inada et al.
patent: 6353011 (2002-03-01), Pershadsingh et al.
patent: 6355808 (2002-03-01), Naka et al.
patent: 6358945 (2002-03-01), Breitfelder et al.
patent: 6369098 (2002-04-01), Pershadsingh et al.
patent: 6372773 (2002-04-01), Regan
patent: 6414002 (2002-07-01), Cheng et al.
patent: 6414008 (2002-07-01), Hauel et al.
patent: 6420405 (2002-07-01), Inada et al.
patent: 6432993 (2002-08-01), Fujita et al.
patent: 6432996 (2002-08-01), Tamura et al.
patent: 6451832 (2002-09-01), Ries et al.
patent: 6468996 (2002-10-01), Jeppesen et al.
patent: 6469039 (2002-10-01), Hauel et al.
patent: 6476023 (2002-11-01), Cirillo et al.
patent: 6479524 (2002-11-01), Priepke et al.
patent: 6486188 (2002-11-01), Pedersen et al.
patent: 2002/0048798 (2002-04-01), Avery et al.
patent: WO 97/25042 (1997-07-01), None
patent: WO 97/28137 (1997-08-01), None
patent: WO 98/05331 (1998-02-01), None
patent: WO 98/57941 (1998-12-01), None
patent: WO 99/62870 (1999-12-01), None
patent: WO 99/62871 (1999-12-01), None
patent: WO 99/62872 (1999-12-01), None
patent: WO 00/27832 (2000-07-01), None
patent: WO 01/00603 (2001-01-01), None
patent: WO 01/12612 (2001-02-01), None
patent: WO 01/21602 (2001-03-01), None
patent: WO 01/34094 (2001-05-01), None
patent: WO-01/82858 (2001-11-01), None
patent: WO-01/82858 (2001-11-01), None
patent: WO 02/076177 (2002-10-01), None
O'Donnell et al., “Irbesartan lowers blood pressure and ameliorates renal injury in experimental non-insulin-dependent diabetes mellitus”, Kidney International, vol. 52, Suppl. 63, pp. S218-S200.
Beers et al., The Merck Manual of Medical Information, Second Edition, (2003), p. 922.
GenBank Accession No. J03258, “Cloning and Expression of Full-Length cDNA Encoding Human Vitamin D Receptor” created on Jan. 14, 1995, located at <http://www.ncbi.nlm.nih.gov> last visited on Sep. 24, 2003.
GenBank Accession No. L02932, “cDNA Cloning, Chromosomal Mapping, and Functional Characterization of the Juman Peroxisome Proliferator Activated Receptor” created on Jul. 26, 1993, located at <http://www.ncbi.nlm.nih.gov> last visited on Sep. 24, 2003.
GenBank Accession No. L13740, “Isolation and Characterization of Human TR3 Receptor: A Member of Steroid Receptor Superfamily” created on Jun. 12, 1993, located at <http://www.ncbi.nlm.nih.gov> last visited on Sep. 24, 2003.
GenBank Accession No. L14160, “The Development of Sequence-Tagged Sites for Human Chromosome 4” created on Aug. 10, 1993, located at <http://www.ncbi.nlm.nih.gov> last visited on Sep. 24, 2003.
GenBank Accession No. L14611, “Identification of Nuclear Receptor mRNAs by RT-PCR Amplification of Conserved Zinc-Finger Motif Sequences” created on Oct. 16, 1993, located at <http://www.ncbi.nlm.nih.gov> last visited on Sep. 24, 2003.
GenBank Accession No. L27586, “Human and Rat TR4 Orphan Receptors Specify a Subclass of the Steroid Receptor Superfamily” created on Sep. 15, 199
Bethesda Pharmaceuticals, Inc.
Kwon Brian
Morrison & Foerster / LLP
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