Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2007-06-19
2007-06-19
Kwon, Brian (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S674000
Reexamination Certificate
active
10489251
ABSTRACT:
The oral administration to genetically alcoholic rats (from the strain UChB of the University of Chile) of a compound selected from endogenic polyamines (putrescine, spermidine, spermine), 1,3-propanediamine, their pharmaceutically acceptable salts and solvates, and their bioprecursor amides, causes a significant reduction in the alcohol consumption. The activity lasts for some time after the treatment period. Besides, there is a virtually null disulfiram-like adverse effect, what constitutes an advantage over the unpleasant use of some anti-alcoholism agents, such as calcium cyanamide or disulfiram itself. Therefore, the compounds of the invention are useful for the preparation of medicaments for the therapeutic and/or prophylactic treatment of alcoholism in human beings.
REFERENCES:
patent: WO 99/48500 (1999-09-01), None
patent: WO 9948500 (1999-09-01), None
Diehl, A. M. et al., “Supplemental putrescine reverses ethanol-associated inhibition of liver regeneration”, abstract of Hepatology vol. 12, No. 4, pp. 633-637, 1990.
Webster's II, New Riverside University Dictionary, 1988, pp. 933 and 944.
Bergeron et al, “Polyamine Analog Regulation of NMDA Binding: A Structure-Activity Study”, Abstract No. 713061 (1996).
Littleton et al, “Role of Polyamines and NMDA Receptors in Ethanol Dependence and Withdrawal”, Abstract No. 200100296358 (May 2001).
Prendergast et al, “In Vitro Effects of Ethanol Withdrawal and Spermidine on Viability of HippoCampus from Male and Female Rat”, Abstract No. 20010055610 (Dec. 2000).
Davidson et al, “Chronic Ethanol Treatment Leads to Increased Ornithine Decarboxylase Activity: Implications for a Role of Polyamines in Ethanol Dependence and Withdrawal”, Abstract No. 199800501861 (Sep. 1998).
Bilbeny Lojo Norberto
Garcia Madrid Hernan
Garbil Pharma Investigacion Chile Ltda.
Kwon Brian
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