Methods and compositions employing a novel stearoyl-CoA...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S189000, C435S325000, C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

10381753

ABSTRACT:
A cDNA encoding a novel human stearoy-CoA desaturase (dubbed “hSCD5”) as well as vectors and cells comprising such polynucleotide are disclosed. Also described are assay methods for determining the ability of small molecules and other chemical agents to increase or decrease the enzymatic activity and/or gene expression level of hSCD5 as well as processes for using such agents to treat, prevent or diagnose a variety of diseases and other conditions.

REFERENCES:
patent: 5336496 (1994-08-01), Akimoto et al.
patent: 5443974 (1995-08-01), Hitz et al.
patent: 6686185 (2004-02-01), Logan et al.
patent: 87301257.9 (1987-02-01), None
patent: 9018234.6 (1990-08-01), None
patent: WO 96/05861 (1996-02-01), None
patent: WO 99/63979 (1999-12-01), None
patent: WO 00/09754 (2000-02-01), None
patent: WO 01/62954 (2001-08-01), None
Sequence search alignment between Applicants' SEQ ID No. 2 taught by Logan et al.
Bretillon, et al., “Effects of Conjugated Linoleic Acid Isomers on the Hepatic Microsomal Desaturation Activities in Vitro,” Lipids, vol. 24, No. 9, pp. 965-969 (1999).
Cao, et al., “Inhibition of fatty acid Δ6- and Δ5-desaturation by cyclopropene fatty acids in rat liver microsomes,” Biochim. Biophys. Acta, vol. 1210, pp. 27-34 (1993).
Choi, et al., “The trans-10, cis-12 Isomer of Conjugated Linoleic Acid Downregulates Stearoyl-CoA Desaturase 1 Gene Expression in 3T3-L1 Adipocytes,” J. Nutritution, vol. 130, pp. 1920-1924 (2000).
Clarke et al., Prog. Lipid Res., 32, 139-149 (1993).
de Antueno, et al., “Relationship Between Mouse liver Δ9 Desaturase Activity,” Lipids, vol. 28, No. 4 (1993).
Grinari, et al., “Conjugated Linoleic Acid is Synthesized Endogenously in Lactating Dairy Cows by Δ9-Desaturase,” J. Nutrition, vol. 130, pp. 2285-2291, (2000).
Hovik, et al., “Thia fatty as substrates and inhibiters of stearoyl-CoA desaturase,” Biochim. Biophys. Acta, vol. 845, pp. 251-256 (1997).
Jeffcoat, et al., “Studies on the Inhibition of the Desaturases by Cyclopropenoid Fatty Acids,” Lipids, vol. 12, pp. 480-485 (1977).
Jeffcoat, et al., “Interrelationship between the Dietary Regulation of Fatty Acid Synthesis and the Fatty Acyl-CoA Desaturases,” Lipids, vol. 12, pp. 469-474 (1977).
Kaestner, et al., “Differentiation-induced Gene Expression in 3T3-L1 Preadipocytes,” Journal of Biological Chemistry, vol. 264, No. 25, pp. 14755-14761 (1991).
Khoo, et al., “Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo,” British J. Cancer, vol. 63, pp. 97-101 (1991).
Kim et al., J. Lipids Res., 41, 1310-1316 (2000).
Kurebayashi S. et al., “Thiazolidinediones Downregulate Stearoyl-CoA Desaturase I Gene Expression in 3T3-L1 Adipocytes”, Diabetes, vol. 46, pp. 2115-2118, Dec. 1997.
Langlois and Mallard, Database Accession No. X60465 (Mar. 5, 1999).
Lefevre, et al., “Hormonal Regulation of Stearoyl Coenzyme-A Desaturase 1 Activity and gene Expression in Primary Cultures of Chicken Hepatocytes,” Archives of Biochemistry and Biophysics, vol. 368, No. 2, pp. 329-337 (Aug. 15, 1999).
Legrand, et al., “Hepatic Δ9 desaturation and plasma VLDL level in genetically lean and fat chickens,” International Journal of Obesity, vol. 16, pp. 289-294 (1992).
Legrand, et al., “Stearoyl-CoA Desaturase Activity in Primary Culture of Chicken Hepatocytes. Influence of Insulin, Glucocorticoid, Fatty Acids and Cordycepin,” Int'l. J. Biochem, vol. 26, No. 6, pp. 777-785 (1994).
Legrand, et al., Effect of Insulin on Triacylglycerol Synthesis and Secretion by Chicken Hepatocyts in Primary Culture, Int'l. J. ′Biochem Cell Bio., vol. 28, No. 4, pp. 431-440 (1996).
Legrand, et al., “Inhibiting Δ9-Desaturase Activity Impairs Triacylglycerol Secretion in Cultured Chicken Hepatocytes” J. Nutrition, vol. 127, pp. 249-256 (1997).
Li, et al., “Partial Characterization of a cDNA for Human Stearoyl-CoA Desaturase and Changes in its mRNA Expression in Some Normal and Malignant Tissues,” Int'l.J. Cancer, vol. 57, pp. 348-352 (1994).
Miyazaki et al., J. Biol. Chem., 275, 30132-30138 (2000).
Ntambi, “Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol,” Journal of Lipid Research, vol. 40, pp. 1549-1558 (1999).
Paisley et al., J. Nutrition, 126, 2730-2737 (1996).
Parimoo et al., J. Invest. Dermatology Symposium Proceedings, 4:320-322 (1999).
Park et al., “Lipid Level and Type Alter Stearoyl CoA Desaturase mRNA Abundance Differently in Mice with Distinct Susceptibilities to Diet-Influenced Diseases”, J. Nutrition, vol. 127, pp. 566-573 (1997).
Park, et al., “Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives,” Biochim. Biophys. Acta, vol. 1486, pp. 285-292 (2000).
Sessler et al., “Regulation-CoA Desaturase 1 mRNA Stability by Polysaturated Fatty Acids in 3T3-L1 Adipocytes”, J. Biol. Chem., vol. 271, No. 47, pp. 29854-29858 (Nov. 22, 1996).
Singh & Ntambi, “Nuclear Factor 1 is Essential Fir the Expression of Stearoyl-CoA Desaturase 1 Gene During Preadipocyte Differentiation”, Biochim. Biophys. Acta., vol. 1398, 1998, pp. 148-156.
Skrede et al., Biochim. Biophys. Acta, 1344, 115-131 (1997).
Strausberg, R., Database Accession No. BE613134 (Aug. 25, 2000).
Waters et al., J. Biol. Chem., 269, 27773-27777 (1994).
Waters & Ntambi: Database Biosis Online. “Polyunsaturated Fatty Acids Inhibit Hepatic Stearoyl-CoA Desaturase-1 Gene in Diabetic Mice”, vol. 31, No. Suppl., pp. S33-S36 (1996), Accession No. PREV199698795704.
Waters et al., “Localization of a Negative Thyroid Hormone-Response Region in Hepatic Stearoyl-CoA Desaturase Gene 1”, Biochem. Biophys. Res. Comm., vol. 233, pp. 838-843, (1997).
Zhang et al., “Human Stearoyl-CoA Desaturase: Alternative Transcripts Generated from a Single Gene by Usage of Tandem Polyadenylation Sites”, Biochem. J., vol. 340, pp. 255-264 (1999).
Zheng et al, “Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse,” Nature Genetics, vol. 23, p. 268 (1999).
Zoeller, et al., “The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatona7288C,” Biochim. Biophys. Acta, vol. 845, pp. 380-388 (1985).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and compositions employing a novel stearoyl-CoA... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions employing a novel stearoyl-CoA..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions employing a novel stearoyl-CoA... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3812017

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.