Substituted alkanoic acids

Details Substituted alkanoic acids Substituted alkanoic acids

2007-01-23

2007-01-23

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S375000, C548S222000, C546S198000

Reexamination Certificate

active

10427598

ABSTRACT:
The invention is directed to physiologically active compounds of general formula (I):wherein:represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a saturated 4 to 6 membered heterocyclic ring;R1represents R3Z1-Het- or R4N(R5)—C(═O)—NH—Ar1—;L1represents an —R6—R7— linkage;R2represents hydrogen, halogen, lower alkyl or lower alkoxy;L2represents an alkylene linkage;Y is carboxy or an acid bioisostere;and their corresponding N-oxides or prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their corresponding N-oxides or prodrugs.Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (α4β1).

REFERENCES:
patent: WO 99/33789 (1999-07-01), None
patent: WO 00/15612 (2000-03-01), None
patent: WO 02/36553 (2002-05-01), None

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