N-heterocyclic retinoic acid analogues

Details N-heterocyclic retinoic acid analogues N-heterocyclic retinoic acid analogues

1983-03-28

1985-07-02

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544335, 544406, 546323, 546326, 548343, 514256, 514354, 514400, 514861, C07D21379, C07D23954, A61K 31505, A61K 31455

Patent

active

045267871

ABSTRACT:
A compound of the formula: ##STR1## where X is ##STR2## and R is hydroxy, or an alkoxy with 0 or 1 hydroxy substituent, or aroxy with 0 or 1 hydroxy substituent, or alkoxy monosubstituted phenoxy, or NR.sup.1 R.sup.2 where R.sup.1 is hydrogen, or an alkyl or aryl with 0 or 1 hydroxy substituent, and R.sup.2 is an alkyl or aryl with 0 or 1 hydroxy substituent. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in ephithelial cells and for treating nonmalignant skin disorders.

REFERENCES:
Boutwell, R. K., et al., "Advances in Enzyme Regulation" vol. 17, ed. Weber, G. Pergamon Press, (1979).
Verma, A. K., et al., "Cancer Res." (1979), 39:419-427.
Dawson, M. I., et al., J. Med. Chem., (1981) 24:583-592, 1214-1223.

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