Transgenic mice comprising a genomic human tau transgene

Details Transgenic mice comprising a genomic human tau transgene Transgenic mice comprising a genomic human tau transgene

2007-01-09

2007-01-09

Chen, Shin-Lin (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S013000, C800S021000, C536S023500, C536S024100, C435S455000

Reexamination Certificate

active

10620840

ABSTRACT:
The invention provides transgenic mice comprising tau transgenes, and methods of preparing and using the transgenic mice. For example, the invention provides a transgenic mouse, the genome of the cells of which stably comprise a DNA molecule which comprises a human genomic DNA sequence comprising a human tau promoter and which DNA sequence encodes human tau.

REFERENCES:
patent: 6593512 (2003-07-01), Vitek et al.
patent: WO-0153340 (2001-07-01), None
Kappel et al., 1992, Current Opinion in Biotechnology, vol. 3, p. 548-553, IDS.
Sigmund, C., Jun. 2000, Arterioscler. Thromb. Vasc. Biol., p. 1425-1429, IDS.
Houdebine, L-M., 2002, Journal of Biotechnology, vol. 98, p. 145-160, IDS.
Lee et al., 1999, Neuron, vol. 24, No. 3, p. 507-510, IDS.
Duff et al., 2000, Neurobiology of diseases, vol. 7, p. 87-98.
Refolo et al., Oct. 1999, Society for Neuroscience Abstracts, vol. 25, No. 1-2, pp. 790, IDS.
Andreadis, A., et al., “Structure and Novel Exons of the Human tau Gene”,Biochemistry, 31, (1992), 10626-10633.
Aranda-Abreu, G E., et al., “Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.”,Journal of Neuroscience, 19(16), (1999), 6907-17.
Behar, L, et al., “cis-acting signals and trans-acting proteins are involved in tau mRNA targeting into neurites of differentiating neuronal cells.”,International Journal of Developmental Neuroscience.13(2), (1995), 113-27.
Braak, E, et al., “A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads”,Acta Neuropathologica.87(6), (1994), 554-67.
Brion, J P., et al., “Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease.”,American Journal of Pathology.154(1), (1999), 255-70.
Dawson, Hana N., et al., “Inhibition of Neuronal Maturation in Primary Hippocampal Neurons from Tau Deficient Mice”,Cell Science, 114, (2001), 1179-1187.
Dawson, Hana N., et al., “Tau Distribution in a Human Tau Gene Transgenic/Mouse Tau Knock-Out Model”,Society for Neuroscience, 25, Miami Beach, FL, Abstract No. 317.1,(1999), 1 pg.
Goedert, M., et al., “Cloning and Sequencing of the cDNA Encoding a Core Protein of the Paired Helical Filament of Alzheimer Disease: Identification as the Microtubule-Associated Protein Tau”,Proc. Natl. Acad. Sci. USA, 85, (Jun. 1988), 4051-4055.
Goedert, M., et al., “Cloning and Sequencing of the cDNA encoding an isoform of microtubule-associated Protein Tau Containing Four Tandem Repeats: differential expression of tau protein mRNAs in human brain”,The EMBO Journal, 8, (1989), 393-399.
Goedert, M, et al., “Tau gene mutation in familial progressive subcortical gliosis”,Nature Medicine. 5(4), (1999), 454-7.
Gotz, J., et al., “Somatodendritic Localization and Hyperphosphorylation of Tau Protein in Transgenic Mice Expressing the Longest Human Brain Tau Isoform”,The EMBO Journal, 14, (1995), 1304-1313.
Grover, A, et al., “5′ splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10”,Journal of Biological Chemistry.274(21), (1999), 15134-43.
Haudebine, L., “The Methods to Generate Transgenic Animals and to Control Transgene Expression”,Journal of Biotechnology, 98, (2002), 145-160.
Ikonomovic, M D., et al., “The loss of GluR2(3) immunoreactivity precedes neurofibrillary tangle formation in the entorhinal cortex and hippocampus of Alzheimer brains”,Journal of Neuropathology&Experimental Neurology, 56(9), (1997), 1018-27.
Jicha, G A., et al., “A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease”,Journal of Neurochemistry. 69(5), (1997), 2087-95.
Jicha, G A., et al., “Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau”,Journal of Neuroscience Research. 48(2), (1997), 128-32.
Jicha, G A., et al., “Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease”,Journal of Neuroscience Research, 55(6), (1999), 713-23.
Kappel, C. A., et al., “Regulating Gene Expression in Transgenic Animals”,Current Opinion in Biotechnology, 3, (1992), 548-553.
Kosik, K S., et al., “Tau in situ hybridization in normal and Alzheimer brain: localization in the somatodendritic compartment”,Annals of Neurology. 26(3), (1989), 352-61.
Lee, V. M., et al., “Neurodegenerative Tauopathies: Human Disease and Transgenic Mouse Models”,Neuron, 24(3), (Nov. 1999), 507-510.
Murrell, J. R., et al., “Familial Multiple-System Tauopathy with Presenile Dementia Is Localized to Chromosome 17”,Am. J. Hum. Genet.,61, (1997), 1131-1138.
Refolo, L., et al., “Phenotype of Transgenic Mice Over-Expressing A Normal Human Tau Gene”,Society for Neuroscience Abstracts, 25 (1-2), (Oct. 1999), 790.
Sigmund, C. D., “Viewpoint: Are Studies in Genetically Altered Mice Out of Control?”,Arterioscler Thromb Vasc Biol,(Jun. 2000), 1425-1429.

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