Probucol nitro-derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S509000, C514S706000, C544S399000, C568S064000, C424S043000, C424S046000, C424S400000, C424S424000, C424S436000, C424S449000, C424S450000, C424S451000, C424S464000, C424S489000

Reexamination Certificate

active

10503128

ABSTRACT:
Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.

REFERENCES:
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patent: 5262439 (1993-11-01), Parthasarathy
patent: 6121319 (2000-09-01), Somers
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patent: WO 2000028332 (2000-05-01), None
patent: WO 01/77072 (2001-04-01), None
patent: WO 01/70757 (2001-09-01), None
Zimetbaum et al., “Probucol: Pharmacology and Clinical Application”,J. Clin. Pharmacol. 30, 3-9, 1990.
Kaul et al., “Probucol treatment reverses antioxidant and functional deficit in diabetic cardiomyopathy”,Mol. Cell. Bichem, 160/161, 283-288, 1996.
Regnström et al., “The effect of probucol on low density lipoprotein oxidation and femoral atherosclerosis”,Atheroscloerosis125, 217-229, 1996.
Lee et al., “Effectiveness of Probucol in Preventing Restenosis after Percutaneous Transluminal Coronary Angioplasty”,Jpn. Heart J. 37(3) 327-332, 2002.
Ishizaki et al., “Effect of probucol, an oral hypocholesterolaemic agent, on acute tobacco smoke inhalation in rats”,Clinical Sci. 90, 517-523, 1996.
Heel et al., “Probucol: A Review of its Pharmacological Properties and Therapeutic Use in Patients with Hypercholesterolaemia”,Drugs15, 409-428, 1978.
Reinoehl et al., “Probucol-associated tachyarrhythmic events and QT prolongatrion: Importance of gender”Am. Heart J. 131(6), 1184-1191, 1992.
Steinberg et al., “Beyond Cholesterol: Modifications of Low-Density Lipoprotein That Increase Its Atherogenicity”,New Eng. J. Med. 320(14), 915-924, 1989.
Heeg et al., “Taux plasmatiques du probucol chez l'homme aprés administration orale unique ou repetee”, Nouv. Presse Med. 9(40), 2990-2994, 1980.

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