Method and apparatus for dynamically monitoring multiple in...

Details Method and apparatus for dynamically monitoring multiple in... Method and apparatus for dynamically monitoring multiple in...

2007-07-24

2007-07-24

Winakur, Eric (Department: 3768)

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

C600S326000, C600S328000

Reexamination Certificate

active

11103963

ABSTRACT:
A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

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patent: 2003/0184757 (2003-10-01), Bevilacqua et al.
Cuccia et al., In Vivo Quant. of Opt. Cont. Agent Dyn. in Rat Tumors By Use of DOS with MRI Coregistration, Applied Optics, vol. 42, No. 16, Jun. 2003.
Merritt et al., Coregistration of DOS and MRI in a Rat Tumor Model, Applied Optics, vol. 42, No. 16, Jun. 2003.

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