Surgery – Diagnostic testing – Respiratory
Reexamination Certificate
2007-04-24
2007-04-24
Pezzuto, Robert E. (Department: 3766)
Surgery
Diagnostic testing
Respiratory
C607S017000, C607S042000, C600S530000, C600S531000, C600S532000, C600S533000, C600S534000, C600S535000, C600S536000, C600S537000, C600S538000, C600S539000, C600S540000, C600S541000, C600S542000, C073S023300, 48
Reexamination Certificate
active
10339989
ABSTRACT:
Techniques are provided for detecting the circadian state of a patient using an implantable medical device based on selected blood carbon dioxide (CO2) parameters. In one example, the implantable device tracks changes in end tidal CO2(etCO2) levels and changes in maximum variations of pCO2levels per breathing cycle (ΔcycleCO2) over the course of the day and determines the circadian state based thereon. It has been found that average etCO2levels are generally highest and average ΔcycleCO2levels are generally lowest while a patient is asleep and opposite while a patient is awake. Hence, by tracking changes in average etCO2and ΔcycleCO2levels over the course of the day, circadian states can be detected. Minute ventilation and activity levels are used to assist in the determination of the circadian state. Additional techniques are directed to detecting the stage of sleep.
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Koh Steve
Park Euljoon
Malamud Deborah
Pacesetter Inc.
Pezzuto Robert E.
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