Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-01-16
2007-01-16
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S368000
Reexamination Certificate
active
10763241
ABSTRACT:
The present invention relates to 2-[4-[2-(7-trifluoromethylbenzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-[4-hydroxy-2,6-bis(trifluoromethyl)phenyl]acetamide or salt thereof, and an intermediate for the preparation thereof.The above-described compound has both an inhibitory action on ACAT in the artery wall and remarkably high metabolic resistance in human liver microsomes, and exhibits excellent effects for suppressing lipids depression in aorta in vivo so that it is useful as a highly effective preventive or remedy for hyperlipidemia and arteriosclerosis with less side effects.
REFERENCES:
patent: WO 98/54153 (1998-12-01), None
patent: WO 03/018564 (2003-03-01), None
Kawaguchi et al. Chemical Abstracts, vol. 123, No. 222345 (1995) (Abstract for JP 07167862 (Jul. 4, 1995).
Vippagunta et al Advanced Drug Delivery Reviews, vol. 48, pp. 3-26 (2001).
P. J. Gillies, et al., Experimental and Molecular Pathology, vol. 44, pp. 329-339, “Regulation of Acyl-CoA: Cholesterol Acyltransferase Activity in Normal and Atherosclerotic Rabbit Aortas: Role of a Cholesterol Substrate Pool”, 1996.
L. Li, et al., Biochimica and Biophysica Acta, vol. 1530, pp. 111-122, “Effects of High-Density Lipoprotein2 on Cholesterol Transport and Acyl-Coenzyme A: Cholesterol Acyltransferase Activity in P388D1 Macrophages”, 2001.
Miura Toru
Shibuya Kimiyuki
Bernhardt Emily
Kowa Co. Ltd.
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