Method for detecting loss of wild-type p53

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S005000, C435S007100, C435S007230, C435S007210

Reexamination Certificate

active

10956348

ABSTRACT:
Methods are provided for restoring wild-type p53 gene function to a cell. Such methods include gene therapy. Typically, this will stop tumor cells from proliferating.

REFERENCES:
patent: 5087617 (1992-02-01), Smith
patent: 5248671 (1993-09-01), Smith
patent: 5527676 (1996-06-01), Vogelstein et al.
patent: 5532220 (1996-07-01), Lee et al.
patent: 6090566 (2000-07-01), Vogelstein et al.
Anderson, W.F. Human Gene Therapy. Nature 392 (Supplement):25-30, Apr. 1998.
Bowie, J.U. et al. Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions. Science 247: 1306-1310, Apr. 1998.
Coghlan, Andy, “Gene dream fades away”, Focus, New Scientist, pp. 14-15, Nov. 25, 1995.
Coghlan. Focus in New Scientist, Nov. 25, 1995 pp. 14-15.
Donahue et al., “Helper Virus Induced T Cell Lymphoma in Nonhuman Primates after Retroviral Mediated Gene Transfer” The Journal of Experimental Medicine, vol. 176, pp. 1125-1135, Oct. 1992.
Eliyahu et al., “Wild-type p53 can inhibit oncogene-mediated focus formation” Proc. Natl. Acad. Science USA., vol. 86, pp. 8763-8767, Nov. 1989.
Finlay et al, Cell, vol. 57, “The p53 Proto-Oncogene Can act as a Suppressor of Transformation”, pp. 1086-1093, Jun. 30, 1989.
Frommel, C. et al. An Estimate on the Effect of Point Mutation and Natural Selection on the Rate of Amino Acid Replacement in Proteins. Journal of Molecular Evolution 21:233-257, 1985.
Hodgson, C.P. Advances in Vector Systems for Gene Therapy. Exp. Opin. Ther. Patents 5(5):459-468, 1995.
Koshland, “p53 Sweeps Through Cancer Research”, Science, 262:1958-1959 (1993).
Marshall, “Gene Therapy's Growing Pains”, Science, vol. 269, pp. 1050-1055, Aug. 1995.
Marshall, “Less Hype, More Biology Needed for Gene Therapy”, Science, vol. 270, p. 1751, Dec. 1995.
Miller, N. et al. Targeted Vectors for Gene Therapy. FASEB Journal 9:190-199, 1995.
Ngo, J.T. et al. Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox in The Protein Folding Problem and Tertiary Structure Prediction (Merz, ed.). Birkhauser, Boston, 1994.
Orkin & Motulsky Report & Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Dec. 7, 1995.
Verma, I.N. Gene Therapy-Promises, Problems and Prospects. Nature 389:239-242, Apr. 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for detecting loss of wild-type p53 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for detecting loss of wild-type p53, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting loss of wild-type p53 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3801129

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.