Soluble inhibitors of vascular endothelial growth factor and...

Details Soluble inhibitors of vascular endothelial growth factor and... Soluble inhibitors of vascular endothelial growth factor and...

2007-09-25

2007-09-25

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S185100

Reexamination Certificate

active

10104610

ABSTRACT:
The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1 and NP-2 are preferred NPs but any neuropilin or VEGF receptor (VEGFR), where the constituents share at least about 85% homology with either of the above VEGF165R/NP-1 and NP-2. More preferably, such constituent shares at least 90% homology. Still more preferably, each constituent shares at least 95% homology.

REFERENCES:
patent: 6204011 (2001-03-01), Kendall et al.
patent: WO94/11499 (1994-05-01), None
patent: WO95/33050 (1995-12-01), None
patent: WO96/40769 (1996-12-01), None
Yamada et al, Blood 97(6): 1671-8, 2001.
Bodey et al, Anticancer Research 20: 2665-2676, 2000.
Ezzell et al, Journal of NIH Research 7: 46-49, 1995.
Spitler et al, Cancer Biotherapy 10: 1-3, 1995.
Soker et al, J Biol Chem 272(50): 31582-88, Dec. 12, 1997.
Dermer et al, Bio/Technology 12: 320, 1994.
Gura et al, Science 278: 1041-1042, Nov. 1997.
T. Omura et al., “Identification of a 190 kDa Vascular Endothelial Growth Factor 165 Cell Surface Binding Protein on a Human Glioma Cell Line,” J. Biol. Chem., 272(37):23317-23322, 1997.
S. Soker et al., “Neuropilin-1 is expressed by endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor,” Cell, 92:735-745, 1998.
S. Soker et al., “Characterization of Novel Vascular Endothelial Growth factor (VEGF) Receptors on Tumor Cells that Bind VEGF165 Via it Exon 7-Encoded Domain,” J. Biol. Chem., 271(10): 5761-5767, 1996.
H. Chen et al., “Neuropilin-2, A Novel Member of the Neuropilin Family, is a High Affinity receptor for the Semaphorins sema E and sema IV but not sema III,” Neuron, 19:547-559, 1997.
A. L. Kolodkin et al., “Neuropilin is a Semaphorin III Receptor,” Cell, 90:753-762, 1997.
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.

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