Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

Details Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

2007-09-18

2007-09-18

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S555000

Reexamination Certificate

active

10872090

ABSTRACT:
This invention provides compounds of formula I having the structurewherein: R1and R2are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated, acyl, or aroyl; R3, R4are H, alkyl, cycloalkyl or —CH2-cycloalkyl; R5is H or alkyl; R6is H or alkyl; and wherein the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods for using these compounds to treat central nervous system disorders, including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

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