Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2007-03-27
2007-03-27
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C424S093100, C424S093700, C424S577000, C424S578000, C435S002000, C435S375000, C435S377000
Reexamination Certificate
active
10186416
ABSTRACT:
We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B cells can be obtained from peripheral blood in large numbers. These cells can be activated in vitro by coculture with CD40L (CD40-B cells) and an immunosuppressive agent such as cyclosporin A. They can expanded up to 1×103to 1×104fold in 2 weeks or 1×105to 1×106fold in 2 months. We demonstrate these cells are most efficient APCs comparable to DCs in stimulating allogeneic CD4+CD45RA+, CD4+CD45RO+, and CD8+T cells. In contrast to DCs, CD40-B cells are fully functional even in the presence of immunosuppressive cytokines such as IL-10 and TGFβ.
REFERENCES:
patent: 5283323 (1994-02-01), Berzofsky et al.
patent: 5662907 (1997-09-01), Kubo et al.
patent: 5820872 (1998-10-01), Edelson et al.
patent: 0434879 (1991-07-01), None
patent: WO 94/20127 (1994-09-01), None
patent: WO 95/29935 (1995-11-01), None
J. Schultze et al.,Blood, vol. 88, No. 10, Suppl. 1, part 1-2, pp. 6-10 (1996).
J. Schultze et al.,Journal of Clinical Investigation, 100(11):2757-2565 (1997).
J. Banchereau et al.,Science, 251(4989):70-72 (1991).
J. Banchereau et al.,Nature, 353(6345):678-679 (1991).
G.J. Freeman et al.,Science, 262:909-911 (1993).
S. Grabbe, et al.,Immunol. Today, 16:117-121 (1995).
K. Inaba et al.,J. Exp. Med., 166:182-194 (1987).
C.H. June et al.,Immunol. Today, 11:211-216 (1990).
C.H. June et al.,Immunol Methods, 164:41-49 (1994).
P.S. Linsley et al.,J. Exp. Med., 173:721-730 (1991).
A. Mackensen et al.,Blood, 86:2699-2707 (1995).
M.C. Nussenzweig et al.,J. Exp. Med., 151:1196 (1980).
P. Paglia. et al.,J. Exp. Med., 183:317-322 (1996).
N. Romani et al.,J. Exp. Med., 180:83-93 (1994).
R.H. Schwartz,Cold Spring Harb Symp Quant Biol., 54:605-610 (1989).
R.H. Schwartz et al.,Cell, 71:1065-1068 (1992).
R.M. Steinman et al.,Annual Review of Immunology, 9:271-296 (1991).
H.M. Steinman et al.,Current Opinion in Immunology, 3:361-372 (1991).
P. Szaboles et al.,J. Immunol., 154:5851-5861 (1995).
J.G. Tew et al.,J. Reticuloendothel Soc., 31:371-380 (1982).
J.W. Young et al.,J. Exp. Med., 183:7-11 (1996).
L. Zitvogel et al.,J. Exp. Med., 183:87-97 (1996).
Fuleihan et al.,J. Clin. Invest., 93:1315-1320 (1994).
Chang et al.,Ann. NY Acad. Sci., 696:108-122 (1993).
Wortis et al.,PNAS, 92:3348-3352 (1995).
Khavkin et al.,Abstr. Annu. Meeting Am. Soc. Microbiol., 90(0):333 (1990).
Banchereau et al.,Ann. Rev. Immunol., 12:881-922 (1994).
Freeman Gordon J.
Gribben John G.
Nadler Lee M.
Schultze Joachim L.
Dana-Farber Cancer Institute Inc.
Gambel Phillip
Nixon & Peabody LLP
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