Pharmaceutical compositions of anti-tubercular drugs and...

Details Pharmaceutical compositions of anti-tubercular drugs and... Pharmaceutical compositions of anti-tubercular drugs and...

2007-03-27

2007-03-27

Padmanabhan, Sreeni (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C424S451000, C424S457000, C424S458000, C424S462000, C424S463000, C424S464000, C424S468000, C424S475000, C424S480000, C424S481000, C424S482000, C424S489000, C424S490000, C424S494000, C424S496000, C424S497000

Reexamination Certificate

active

10110134

ABSTRACT:
A pharmaceutical composition of anti-tubercular drugs for oral use comprising Rifampicin and/or Isoniazid wherein the bioavailability of Rifampicin and/or other drugs is enhanced. Preferably the bioavailability of Rifampicin is enhanced by preventing its degradation caused by presence of Isoniazid. Rifampicin and/or Isoniazid may be present in delayed release and/or extended release form such that minimal amount of the drug is dissolved between pH 1 and 4. preferably delayed release of Rifampicin and/or Isoniazid is achieved by treating the drugs with pH sensitive polymers.

REFERENCES:
patent: 5439891 (1995-08-01), Kapil et al.
patent: 6264991 (2001-07-01), Barrow et al.
patent: 1 010 972 (1999-03-01), None
patent: 2 135 879 (1984-09-01), None
patent: 99 47123 (1999-09-01), None
Shishoo et al (International Journal of Pharmaceutics 190 (1999), 109-123).
Eier et al (Therapy of tuberculosis, Wien Med Wochenschr, 1994; 144(8-9): 186-8).

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